| Autor: |
Dzięgielewska-Gęsiak S; Department of Internal Medicine, Medical University of Silesia in Katowice, Bytom 41-902, Poland., Stołtny D; Department of Internal Medicine, Medical University of Silesia in Katowice, Bytom 41-902, Poland., Brożek A; Department of Clinical Biochemistry and Laboratory Medicine, Poznan University of Medical Sciences, Poznan 60-806, Poland., Muc-Wierzgoń M; Department of Internal Medicine, Medical University of Silesia in Katowice, Bytom 41-902, Poland., Wysocka E; Chair and Department of Laboratory Diagnostics, Poznan University of Medical Sciences, Poznan 60-569, Poland. |
| Jazyk: |
angličtina |
| Zdroj: |
Experimental biology and medicine (Maywood, N.J.) [Exp Biol Med (Maywood)] 2020 Aug; Vol. 245 (14), pp. 1260-1267. Date of Electronic Publication: 2020 May 29. |
| DOI: |
10.1177/1535370220929621 |
| Abstrakt: |
Impact Statement: Insulin resistance is associated with oxidative stress leading to cardiovascular diseases. However, little research has been performed examining elderly individuals with or without insulin-resistance. We demonstrate that antioxidant defense systems alone is not able to abrogate insulin action in elderly individuals at high risk for atherosclerosis, whereas the combined oxidant-antioxidant markers (thiobarbituric acid-reacting substances (TBARS), Cu,Zn-superoxide dismutase (SOD-1), and total antioxidant status (TAS)) might be more efficient and perhaps produce better clinical outcome. In fact, a decrease in oxidative stress and strong interaction between antioxidant defense can be seen only among insulin-resistant elderly individuals. This is, in our opinion, valuable information for clinicians, since insulin-resistance is considered strong cardiovascular risk factor. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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