Influenza vaccine effectiveness and disease burden in children and adolescents with sickle cell disease: 2012-2017.

Autor: Kao CM; Emory University School of Medicine, Department of Pediatrics, Division of Infectious Diseases, Atlanta, Georgia., Lai K; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia., McAteer JM; Emory University School of Medicine, Department of Pediatrics, Division of Infectious Diseases, Atlanta, Georgia., Elmontser M; Emory University School of Medicine, Department of Pediatrics, Division of Infectious Diseases, Atlanta, Georgia., Quincer EM; Emory University School of Medicine, Department of Pediatrics, Division of Infectious Diseases, Atlanta, Georgia., Yee MEM; Emory University School of Medicine, Department of Pediatrics, Division of Hematology/Oncology, Atlanta, Georgia.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia., Tippet A; Emory University School of Medicine, Department of Pediatrics, Division of Infectious Diseases, Atlanta, Georgia., Jerris RC; Emory University School of Medicine, Department of Pediatrics, Division of Infectious Diseases, Atlanta, Georgia., Lane PA; Emory University School of Medicine, Department of Pediatrics, Division of Hematology/Oncology, Atlanta, Georgia.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia., Anderson EJ; Emory University School of Medicine, Department of Pediatrics, Division of Infectious Diseases, Atlanta, Georgia., Bakshi N; Emory University School of Medicine, Department of Pediatrics, Division of Hematology/Oncology, Atlanta, Georgia.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia., Yildirim I; Emory University School of Medicine, Department of Pediatrics, Division of Infectious Diseases, Atlanta, Georgia.; Department of Epidemiology, Rollins School of Public Health, Atlanta, Georgia.
Jazyk: angličtina
Zdroj: Pediatric blood & cancer [Pediatr Blood Cancer] 2020 Aug; Vol. 67 (8), pp. e28358. Date of Electronic Publication: 2020 May 29.
DOI: 10.1002/pbc.28358
Abstrakt: Background: Data are limited on the burden of influenza and seasonal influenza vaccine effectiveness (VE) in children with sickle cell disease (SCD).
Methods: We used a prospectively collected clinical registry of SCD patients 6 months to 21 years of age to determine the influenza cases per 100 patient-years, vaccination rates, and a test-negative case-control study design to estimate influenza VE against medically attended laboratory-confirmed influenza infection. Influenza-positive cases were randomly matched to test-negative controls on age and influenza season in 1:1 ratio. We used adjusted logistic regression models to compare odds ratio (OR) of vaccination in cases to controls. We calculated VE as [100% × (1 - adjusted OR)] and computed 95% confidence intervals (CIs) around the estimate.
Results: There were 1037 children with SCD who were tested for influenza, 307 children (29.6%) had at least one influenza infection (338 infections, incidence rate 3.7 per 100 person-years; 95% CI, 3.4-4.1) and 56.2% of those tested received annual influenza vaccine. Overall VE pooled over five seasons was 22.3% (95% CI, -7.3% to 43.7%). Adjusted VE estimates ranged from 39.7% (95% CI, -70.1% to 78.6%) in 2015/2016 to -5.9% (95% CI, -88.4% to 40.4%) in the 2016/17 seasons. Influenza VE varied by age and was highest in children 1-5 years of age (66.6%; 95% CI, 30.3-84.0). Adjusted VE against acute chest syndrome during influenza infection was 39.4% (95% CI, -113.0 to 82.8%).
Conclusions: Influenza VE in patients with SCD varies by season and age. Multicenter prospective studies are needed to better establish and monitor influenza VE among children with SCD.
(© 2020 Wiley Periodicals LLC.)
Databáze: MEDLINE
Externí odkaz: