Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders : Evidence through univariate and multivariate mega-analysis including 6420 participants from the ENIGMA MDD working group.

Autor: Opel N; Department of Psychiatry, University of Münster, Münster, Germany. n_opel01@uni-muenster.de.; Interdisciplinary Centre for Clinical Research (IZKF), University of Münster, Münster, Germany. n_opel01@uni-muenster.de., Thalamuthu A; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.; Neuroscience Research Australia, Randwick, NSW, Australia., Milaneschi Y; Department of Psychiatry, Amsterdam UMC/Vrije Universiteit, Amsterdam, Netherlands., Grotegerd D; Department of Psychiatry, University of Münster, Münster, Germany., Flint C; Department of Psychiatry, University of Münster, Münster, Germany.; Faculty of Mathematics and Computer Science, University of Münster, Münster, Germany., Leenings R; Department of Psychiatry, University of Münster, Münster, Germany., Goltermann J; Department of Psychiatry, University of Münster, Münster, Germany., Richter M; Department of Psychiatry, University of Münster, Münster, Germany., Hahn T; Department of Psychiatry, University of Münster, Münster, Germany., Woditsch G; IT Department, University of Muenster, Münster, Germany., Berger K; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany., Hermesdorf M; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany., McIntosh A; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Whalley HC; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Harris MA; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., MacMaster FP; Psychiatry and Paediatrics, University of Calgary, Calgary, AB, Canada.; Addictions and Mental Health Strategic Clinical Network Calgary, Calgary, AB, Canada., Walter H; Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Veer IM; Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Frodl T; Department of Psychiatry, Trinity College Dublin, Dublin, Ireland.; Department of Psychiatry and Psychotherapy, Otto von Guericke University Magdeburg, Magdeburg, Germany., Carballedo A; Department of Psychiatry, Trinity College Dublin, Dublin, Ireland., Krug A; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Nenadic I; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Kircher T; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Aleman A; Department of Biomedical Sciences of Cells and Systems, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Groenewold NA; Department of Biomedical Sciences of Cells and Systems, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Stein DJ; SA MRC Unit on Risk & Resilience, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Soares JC; UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA., Zunta-Soares GB; UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA., Mwangi B; Department of Psychiatry, University of Texas Health Science Center at Houston, Houston, TX, USA., Wu MJ; Department of Psychiatry, University of Texas Health Science Center at Houston, Houston, TX, USA., Walter M; Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany., Li M; Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany., Harrison BJ; Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Parkville, VIC, Australia., Davey CG; Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, VIC, Australia.; Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia., Cullen KR; Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Minnesota, Minneapolis, MN, USA., Klimes-Dougan B; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Mueller BA; Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Minnesota, Minneapolis, MN, USA., Sämann PG; Max Planck Institute of Psychiatry, Munich, Germany., Penninx B; Department of Psychiatry, Amsterdam UMC/Vrije Universiteit, Amsterdam, Netherlands., Nawijn L; Department of Psychiatry, Amsterdam UMC/Vrije Universiteit, Amsterdam, Netherlands., Veltman DJ; Department of Psychiatry, Amsterdam UMC/Vrije Universiteit, Amsterdam, Netherlands., Aftanas L; FSSBI 'Scientific Research Institute of Physiology & Basic Medicine', Laboratory of Affective, Cognitive & Translational Neuroscience, Novosibirsk, Russia., Brak IV; FSSBI 'Scientific Research Institute of Physiology & Basic Medicine', Laboratory of Affective, Cognitive & Translational Neuroscience, Novosibirsk, Russia., Filimonova EA; FSSBI 'Scientific Research Institute of Physiology & Basic Medicine', Laboratory of Affective, Cognitive & Translational Neuroscience, Novosibirsk, Russia., Osipov EA; Novosibirsk State University, Laboratory of Experimental & Translational Neuroscience, Novosibirsk, Russia., Reneman L; Department of Radiology and Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands., Schrantee A; Department of Radiology and Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; German Center for Neurodegenerative Diseases (DZNE), Greifswald/Rostock, site Greifswald, Greifswald, Germany., Van der Auwera S; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; German Center for Neurodegenerative Diseases (DZNE), Greifswald/Rostock, site Greifswald, Greifswald, Germany., Wittfeld K; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; German Center for Neurodegenerative Diseases (DZNE), Greifswald/Rostock, site Greifswald, Greifswald, Germany., Hosten N; Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany., Völzke H; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany., Sim K; West Region, Institute of Mental Health, Singapore, Singapore.; Yoo Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Gotlib IH; Department of Psychology, Stanford University, Stanford, CA, USA., Sacchet MD; Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Belmont, MA, USA., Lagopoulos J; Sunshine Coast Mind and Neuroscience Thompson Institute, University of the Sunshine Coast, Sippy Downs, QLD, Australia., Hatton SN; Brain and Mind Centre, University of Sydney, Camperdown, NSW, Australia., Hickie I; Brain and Mind Centre, University of Sydney, Camperdown, NSW, Australia., Pozzi E; Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, VIC, Australia.; Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Parkville, VIC, Australia., Thompson PM; Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Jahanshad N; Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Schmaal L; Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, VIC, Australia.; Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia., Baune BT; Department of Psychiatry, University of Münster, Münster, Germany.; Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, VIC, Australia.; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia., Dannlowski U; Department of Psychiatry, University of Münster, Münster, Germany.
Jazyk: angličtina
Zdroj: Molecular psychiatry [Mol Psychiatry] 2021 Sep; Vol. 26 (9), pp. 4839-4852. Date of Electronic Publication: 2020 May 28.
DOI: 10.1038/s41380-020-0774-9
Abstrakt: Emerging evidence suggests that obesity impacts brain physiology at multiple levels. Here we aimed to clarify the relationship between obesity and brain structure using structural MRI (n = 6420) and genetic data (n = 3907) from the ENIGMA Major Depressive Disorder (MDD) working group. Obesity (BMI > 30) was significantly associated with cortical and subcortical abnormalities in both mass-univariate and multivariate pattern recognition analyses independent of MDD diagnosis. The most pronounced effects were found for associations between obesity and lower temporo-frontal cortical thickness (maximum Cohen´s d (left fusiform gyrus) = -0.33). The observed regional distribution and effect size of cortical thickness reductions in obesity revealed considerable similarities with corresponding patterns of lower cortical thickness in previously published studies of neuropsychiatric disorders. A higher polygenic risk score for obesity significantly correlated with lower occipital surface area. In addition, a significant age-by-obesity interaction on cortical thickness emerged driven by lower thickness in older participants. Our findings suggest a neurobiological interaction between obesity and brain structure under physiological and pathological brain conditions.
(© 2020. The Author(s).)
Databáze: MEDLINE
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