Haematopoietic stem cell self-renewal in vivo and ex vivo.

Autor: Wilkinson AC; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Igarashi KJ; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Nakauchi H; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA. nakauchi@stanford.edu.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. nakauchi@stanford.edu.; Division of Stem Cell Therapy, Distinguished Professor Unit, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. nakauchi@stanford.edu.
Jazyk: angličtina
Zdroj: Nature reviews. Genetics [Nat Rev Genet] 2020 Sep; Vol. 21 (9), pp. 541-554. Date of Electronic Publication: 2020 May 28.
DOI: 10.1038/s41576-020-0241-0
Abstrakt: The self-renewal capacity of multipotent haematopoietic stem cells (HSCs) supports blood system homeostasis throughout life and underlies the curative capacity of clinical HSC transplantation therapies. However, despite extensive characterization of the HSC state in the adult bone marrow and embryonic fetal liver, the mechanism of HSC self-renewal has remained elusive. This Review presents our current understanding of HSC self-renewal in vivo and ex vivo, and discusses important advances in ex vivo HSC expansion that are providing new biological insights and offering new therapeutic opportunities.
Databáze: MEDLINE
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