The human tumor microbiome is composed of tumor type-specific intracellular bacteria.

Autor:	Nejman D; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Livyatan I; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel., Fuks G; Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel., Gavert N; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Zwang Y; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Geller LT; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Rotter-Maskowitz A; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Weiser R; Division of Surgery, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel., Mallel G; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Gigi E; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Meltser A; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Douglas GM; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada., Kamer I; Institute of Oncology, Sheba Medical Center, Ramat Gan, Israel., Gopalakrishnan V; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Dadosh T; Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel., Levin-Zaidman S; Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel., Avnet S; Orthopaedic Pathophysiology and Regenerative Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Atlan T; Department of Bioinformatics, Jerusalem College of Technology, Jerusalem, Israel., Cooper ZA; Translational Medicine, Oncology R&D, AstraZeneca, Gaithersburg, MD, USA., Arora R; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Cogdill AP; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Khan MAW; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ologun G; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bussi Y; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Weinberger A; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel., Lotan-Pompan M; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel., Golani O; Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Perry G; Cancer Research Center, Sheba Medical Center, Ramat Gan, Israel., Rokah M; Department of Thoracic Surgery, Sheba Medical Center, Ramat Gan, Israel., Bahar-Shany K; Cancer Research Center, Sheba Medical Center, Ramat Gan, Israel., Rozeman EA; Department of Medical Oncology and Division of Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands., Blank CU; Department of Medical Oncology and Division of Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands., Ronai A; Pediatric Gastroenterology Institute, Rambam Medical Center, Haifa, Israel., Shaoul R; Pediatric Gastroenterology Institute, Rambam Medical Center, Haifa, Israel., Amit A; Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.; Department of Obstetrics and Gynecology, Rambam Health Care Campus, Haifa, Israel., Dorfman T; Division of General Surgery, Rambam Health Care Campus, Haifa, Israel.; Ambulatory and Breast Surgery Service, Rambam Health Care Campus, Haifa, Israel., Kremer R; Department of Thoracic Surgery, Rambam Health Care Campus, Haifa, Israel., Cohen ZR; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.; Department of Neurosurgery, Sheba Medical Center, Ramat Gan, Israel., Harnof S; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.; Department of Neurosurgery, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel., Siegal T; Neuro-Oncology Unit, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel., Yehuda-Shnaidman E; Institute of Pathology, Megalab, Maccabi Healthcare Services, Rehovot, Israel., Gal-Yam EN; Breast Oncology Institute, Sheba Medical Center, Ramat Gan, Israel., Shapira H; Institute of Pathology, Megalab, Maccabi Healthcare Services, Rehovot, Israel., Baldini N; Orthopaedic Pathophysiology and Regenerative Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy., Langille MGI; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.; Department of Pharmacology, Dalhousie University, Halifax, NS, Canada., Ben-Nun A; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.; Department of Thoracic Surgery, Sheba Medical Center, Ramat Gan, Israel., Kaufman B; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.; Institute of Oncology, Sheba Medical Center, Ramat Gan, Israel., Nissan A; Department of Surgical Oncology (Surgery C), Sheba Medical Center, Ramat Gan, Israel., Golan T; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.; Institute of Oncology, Sheba Medical Center, Ramat Gan, Israel., Dadiani M; Cancer Research Center, Sheba Medical Center, Ramat Gan, Israel., Levanon K; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.; Cancer Research Center, Sheba Medical Center, Ramat Gan, Israel., Bar J; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.; Institute of Oncology, Sheba Medical Center, Ramat Gan, Israel., Yust-Katz S; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.; Neuro-Oncology Unit, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel., Barshack I; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.; Department of Pathology, Sheba Medical Center, Ramat Gan, Israel., Peeper DS; Division of Molecular Oncology & Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands., Raz DJ; Division of Thoracic Surgery, City of Hope Medical Center, Duarte, CA, USA., Segal E; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel., Wargo JA; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Sandbank J; Institute of Pathology, Megalab, Maccabi Healthcare Services, Rehovot, Israel., Shental N; Department of Mathematics and Computer Science, The Open University of Israel, Ra'anana, Israel., Straussman R; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. ravidst@weizmann.ac.il.
Jazyk:	angličtina
Zdroj:	Science (New York, N.Y.) [Science] 2020 May 29; Vol. 368 (6494), pp. 973-980.
DOI:	10.1126/science.aay9189
Abstrakt:	Bacteria were first detected in human tumors more than 100 years ago, but the characterization of the tumor microbiome has remained challenging because of its low biomass. We undertook a comprehensive analysis of the tumor microbiome, studying 1526 tumors and their adjacent normal tissues across seven cancer types, including breast, lung, ovary, pancreas, melanoma, bone, and brain tumors. We found that each tumor type has a distinct microbiome composition and that breast cancer has a particularly rich and diverse microbiome. The intratumor bacteria are mostly intracellular and are present in both cancer and immune cells. We also noted correlations between intratumor bacteria or their predicted functions with tumor types and subtypes, patients' smoking status, and the response to immunotherapy. (Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)
Databáze:	MEDLINE
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