| Autor: |
De Franceschi L; Section of Internal Medicine, Department of Medicine, University of Verona, 37134 Verona, Italy., Gabbiani D; Section of Internal Medicine, Department of Medicine, University of Verona, 37134 Verona, Italy., Giusti A; Rheumatology Unit, Department of Locomotor System, La Colletta Hospital, 16011 Arenzano, Italy., Forni G; Centro della Microcitemia, Anemie Congenite, Galliera Hospital, 16128 Genova, Italy., Stefanoni F; Section of Internal Medicine, Department of Medicine, University of Verona, 37134 Verona, Italy., Pinto VM; Centro della Microcitemia, Anemie Congenite, Galliera Hospital, 16128 Genova, Italy., Sartori G; Section of Internal Medicine, Department of Medicine, University of Verona, 37134 Verona, Italy., Balocco M; Centro della Microcitemia, Anemie Congenite, Galliera Hospital, 16128 Genova, Italy., Dal Zotto C; Section of Internal Medicine, Department of Medicine, University of Verona, 37134 Verona, Italy., Valenti MT; Section of Internal Medicine, Department of Medicine, University of Verona, 37134 Verona, Italy., Dalle Carbonare L; Section of Internal Medicine, Department of Medicine, University of Verona, 37134 Verona, Italy. |
| Abstrakt: |
Sickle-cell disease (SCD) is a worldwide distributed hemoglobinopathy, characterized by hemolytic anemia associated with vaso-occlusive events. These result in acute and chronic multiorgan damage. Bone is early involved, leading to long-term disability, chronic pain and fractures. Here, we carried out a retrospective study to evaluate sickle bone disease (SBD) in a cohort of adults with SCD. We assessed bone density, metabolism and turnover. We also evaluated the presence of fractures and the correlation between SCD severity and skeletal manifestations. A total of 71 patients with SCD were analyzed. The mean age of population was 39 ± 10 years, 56% of which were females. We found osteoporosis in a range between 7% and 18% with a high incidence of vertebral fractures. LDH and AST were predictive for the severity of vertebral fractures, while bone density was not. Noteworthy, we identified -1.4 Standard Deviations T -score as the cutoff for detecting the presence of fractures in patients with SCD. Collectively our data allowed us to develop an algorithm for the management of SBD, which may be useful in daily clinical practice to early intersect and treat SBD. |
