Solvent induced supramolecular polymorphism in Cu(II) coordination complex built from 1,2,4-triazolo[1,5-a]pyrimidine: Crystal structures and anti-oxidant activity.

Autor: Chkirate K; LCOH, Département de Chimie, Faculté des Sciences, Université Mohamed V, BP1014, Rabat 10100, Morocco., Fettach S; Biopharmaceutical and Toxicological Analysis Research Team, Laboratory of Pharmacology and Toxicology, Pharmacokinetic Research Team, Faculty of Medicine and Pharmacy, University Mohammed V of Rabat, Morocco., El Hafi M; LCOH, Département de Chimie, Faculté des Sciences, Université Mohamed V, BP1014, Rabat 10100, Morocco., Karrouchi K; Laboratory of Analytical Chemistry and Bromatology, Faculty of Medicine and Pharmacy, Mohamed V University, Rabat, Morocco., Elotmani B; LCOH, Département de Chimie, Faculté des Sciences, Université Mohamed V, BP1014, Rabat 10100, Morocco., Mague JT; Department of Chemistry, Tulane University, New Orleans, LA 70118, USA., Radi S; LCAE, Département de Chimie, Faculté des Sciences, Université Mohamed I, BP 524, 60 000 Oujda, Morocco., Faouzi MEA; Biopharmaceutical and Toxicological Analysis Research Team, Laboratory of Pharmacology and Toxicology, Pharmacokinetic Research Team, Faculty of Medicine and Pharmacy, University Mohammed V of Rabat, Morocco., Adarsh NN; Institute of Condensed Matter and Nanosciences, Molecular Chemistry, Materials and Catalysis (IMCN/MOST), Université catholique de Louvain, Place L. Pasteur 1, 1348 Louvain-la-Neuve, Belgium., Essassi EM; LCOH, Département de Chimie, Faculté des Sciences, Université Mohamed V, BP1014, Rabat 10100, Morocco., Garcia Y; Institute of Condensed Matter and Nanosciences, Molecular Chemistry, Materials and Catalysis (IMCN/MOST), Université catholique de Louvain, Place L. Pasteur 1, 1348 Louvain-la-Neuve, Belgium. Electronic address: yann.garcia@uclouvain.be.
Jazyk: angličtina
Zdroj: Journal of inorganic biochemistry [J Inorg Biochem] 2020 Jul; Vol. 208, pp. 111092. Date of Electronic Publication: 2020 May 05.
DOI: 10.1016/j.jinorgbio.2020.111092
Abstrakt: Two Cu(II) coordination complexes, C1 and C2 of the formula [Cu(4) 2 (H 2 O) 2 ], have been prepared by reaction between CuCl 2 ·2H 2 O and 7-ethoxycarbonylmethyl-5-methyl-1,2,4[1,5-a]pyrimidine (L) in a 1:2 M:L molar ratio. The L molecule decomposes during the reaction process into 7-carboxy-5-methyl-[1,2,4]-triazolo[1,5-a]pyrimidine (4) through an intermediate, ethyl 2,2-dihydroxy-2-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)acetate (5), which has been isolated and its crystal structure determined by X-ray diffraction. The X-ray analysis of the single crystals of [Cu(4) 2 (H 2 O) 2 ] obtained from the slow evaporation of EtOH and MeOH, separately, revealed the formation of "solvent induced" polymorphs C1 and C2, respectively. The primary supramolecular synthon for C1 and C2 are six membered ring, and square shaped hydrogen bonded architecture, respectively. The self-assembly of such synthons resulted in a two dimensional hydrogen bonded sheet supported by OH⋯O interactions. In addition, the antioxidant properties of the ligands and its complexes were evaluated in vitro using 1,1-diphenyl-2-picrylhydrazyl acid, 2,2'-azino-bis (3-ethylbenzothiazoline-6 sulfonic acid radical scavenging methods and ferric reducing antioxidant power.
Competing Interests: Declaration of competing interest There is no conflict of interest to declare.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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