Effectiveness of micronized nasal irrigations with hyaluronic acid/isotonic saline solution in non-polipoid chronic rhinosinusitis: A prospective, randomized, double-blind, controlled study.

Autor: Savietto E; Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy., Marioni G; Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy., Maculan P; Department of Cardiac Thoracic and Vascular Sciences and Public Health, Hygiene and Public Health Section, University of Padova, Padova, Italy., Pettorelli A; Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy., Scarpa B; Department of Statistical Sciences, University of Padova, Padova, Italy; Department of Mathematics 'Tullio Levi-Civita', University of Padova, Padova, Italy., Simoni E; Department of Neuroscience, Bioacoustics Research Laboratory, University of Padova, Padova, Italy., Astolfi L; Department of Neuroscience, Bioacoustics Research Laboratory, University of Padova, Padova, Italy., Marchese-Ragona R; Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy., Ottaviano G; Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy. Electronic address: giancarlo.ottaviano@unipd.it.
Jazyk: angličtina
Zdroj: American journal of otolaryngology [Am J Otolaryngol] 2020 Jul - Aug; Vol. 41 (4), pp. 102502. Date of Electronic Publication: 2020 May 07.
DOI: 10.1016/j.amjoto.2020.102502
Abstrakt: Background: Sodium hyaluronate has been proposed as a treatment for improving the symptoms of chronic rhinosinusitis. The present study evaluated the effect of the intranasal administration of hyaluronic acid in a group of patients affected by chronic rhinosinusitis without nasal polyps (CRSsNP).
Materials and Methods: Thirty subjects aged 18-65 years affected by CRSsNP were enrolled. The subjects were randomly administered hyaluronic acid or isotonic saline solution by nasal nebulizer twice per day for 30 days. They were evaluated before (T0) and after the treatment (T1) with Sino-Nasal Outcome Test-22, visual analogue scale for rhinorrhea, nasal obstruction, facial pain and hyposmia/hypogeusia, nasal endoscopy, active anterior rhinomanometry, peak nasal inspiratory flow and nasal cytology.
Results: Comparing the study and the control group, at T1 no significant differences were observed in both objective and subjective parameters. Being included in the study group rather than in the control group did not have a significant effect on the variation of the considered parameters between T0 and T1. Considering the effects of the micronized douches independently from the type of solution used (either hyaluronic acid or isotonic saline solution), although no difference emerged between study and control group for any of the objective parameters, there was an improvement of Sino-Nasal Outcome Test-22 scores (p = .0005), visual analogue scale for nasal obstruction (p = .0006) and for hyposmia/hypogeusia (p = .04).
Conclusions: The treatment with micronized nasal douches can improve the sino-nasal symptoms of CRSsNP, in particular nasal obstruction and olfactory ability. No advantage of the use of hyaluronic acid over isotonic saline solution emerged.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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