Cerebral Metabolic Changes During Visuomotor Adaptation Assessed Using Quantitative fMRI.

Autor: Foster C; Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom., Steventon JJ; Cardiff University Brain Research Imaging Centre (CUBRIC), School of Physics and Astronomy, Cardiff University, Cardiff, United Kingdom.; Neuroscience and Mental Health Research Institute (NMHRI), School of Medicine, Cardiff University, Cardiff, United Kingdom., Helme D; Department of Anaesthetics and Intensive Care Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom., Tomassini V; Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom.; Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.; Department of Neuroscience, Imaging and Clinical Sciences, 'G. D'Annunzio University' of Chieti-Pescara, Chieti, Italy.; Institute for Advanced Biomedical Technologies (ITAB), 'G. D'Annunzio University' of Chieti-Pescara, Chieti, Italy., Wise RG; Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom.; Department of Neuroscience, Imaging and Clinical Sciences, 'G. D'Annunzio University' of Chieti-Pescara, Chieti, Italy.; Institute for Advanced Biomedical Technologies (ITAB), 'G. D'Annunzio University' of Chieti-Pescara, Chieti, Italy.
Jazyk: angličtina
Zdroj: Frontiers in physiology [Front Physiol] 2020 May 08; Vol. 11, pp. 428. Date of Electronic Publication: 2020 May 08 (Print Publication: 2020).
DOI: 10.3389/fphys.2020.00428
Abstrakt: The brain retains a lifelong ability to adapt through learning and in response to injury or disease-related damage, a process known as functional neuroplasticity. The neural energetics underlying functional brain plasticity have not been thoroughly investigated experimentally in the healthy human brain. A better understanding of the blood flow and metabolic changes that accompany motor skill acquisition, and which facilitate plasticity, is needed before subsequent translation to treatment interventions for recovery of function in disease. The aim of the current study was to characterize cerebral blood flow (CBF) and oxygen consumption (relative CMRO 2 ) responses, using calibrated fMRI conducted in 20 healthy participants, during performance of a serial reaction time task which induces rapid motor adaptation. Regions of interest (ROIs) were defined from areas showing task-induced BOLD and CBF responses that decreased over time. BOLD, CBF and relative CMRO 2 responses were calculated for each block of the task. Motor and somatosensory cortices and the cerebellum showed statistically significant positive responses to the task compared to baseline, but with decreasing amplitudes of BOLD, CBF, and CMRO 2 response as the task progressed. In the cerebellum, there was a sustained positive BOLD response in the absence of a significant CMRO 2 increase from baseline, for all but the first task blocks. This suggests that the brain may continue to elevate the supply energy even after CMRO 2 has returned to near baseline levels. Relying on BOLD fMRI data alone in studies of plasticity may not reveal the nature of underlying metabolic responses and their changes over time. Calibrated fMRI approaches may offer a more complete picture of the energetic changes supporting plasticity and learning.
(Copyright © 2020 Foster, Steventon, Helme, Tomassini and Wise.)
Databáze: MEDLINE
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