Pro12Ala Polymorphism on the PPAR γ 2 Gene and Weight Loss After Aerobic Training: A Randomized Controlled Trial.

Autor:	Cardoso GA; Laboratory of Applied Studies in Physical Training to Performance and Health - LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, Brazil.; Associate Graduate Program in Physical Education - UPE/UFPB, Department of Physical Education, Federal University of Paraíba, João Pessoa, Brazil., Persuhn DC; Graduate Program in Nutrition Sciences, Federal University of Paraíba (PPGCN/UFPB), João Pessoa, Brazil., Ribeiro MD; Laboratory of Applied Studies in Physical Training to Performance and Health - LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, Brazil.; Associate Graduate Program in Physical Education - UPE/UFPB, Department of Physical Education, Federal University of Paraíba, João Pessoa, Brazil., de Sousa BRV; Laboratory of Applied Studies in Physical Training to Performance and Health - LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, Brazil.; Graduate Program in Nutrition Sciences, Federal University of Paraíba (PPGCN/UFPB), João Pessoa, Brazil., Sena KF; Laboratory of Applied Studies in Physical Training to Performance and Health - LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, Brazil.; Associate Graduate Program in Physical Education - UPE/UFPB, Department of Physical Education, Federal University of Paraíba, João Pessoa, Brazil., de Almeida AEM; Lauro Wanderley University Hospital - HULW-Federal University of Paraíba - UFPB, João Pessoa, Brazil., Modesto-Filho J; Lauro Wanderley University Hospital - HULW-Federal University of Paraíba - UFPB, João Pessoa, Brazil., da Silva RSB; Laboratory of Applied Studies in Physical Training to Performance and Health - LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, Brazil.; Associate Graduate Program in Physical Education - UPE/UFPB, Department of Physical Education, Federal University of Paraíba, João Pessoa, Brazil., Silva AS; Laboratory of Applied Studies in Physical Training to Performance and Health - LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, Brazil.; Associate Graduate Program in Physical Education - UPE/UFPB, Department of Physical Education, Federal University of Paraíba, João Pessoa, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in physiology [Front Physiol] 2020 May 08; Vol. 11, pp. 385. Date of Electronic Publication: 2020 May 08 (Print Publication: 2020).
DOI:	10.3389/fphys.2020.00385
Abstrakt:	The objective of this study was to verify the influence of the Pro12Ala polymorphism of the PPARγ2 gene in response of a training program on the body composition. Sixty-nine previously inactive men and women (32.8 ± 8.2 years) were genotyped and underwent a 12-week aerobic (running/walking) training program (3-5 sessions, 40 - 60 min per session, and intensity between the aerobic and anaerobic threshold) (experimental group n = 53) or were part of the control group ( n = 16). They were tested for aerobic capacity (ergospirometry), body composition (DXA), abdomen, waist and hip circumferences and nutritional assessment before and 48 h after the experimental protocol. Two-way repeated measures ANOVA test was used to verify possible differences in variables between the experimental vs. control groups or Pro/Pro vs. Pro/Ala groups, and the Chi-squared test was used to verify the distribution of responders and non-responders according to genotype ( p < 0.05). Frequencies of 75.5% Pro/Pro ( n = 40) and 24.5% Pro/Ala ( n = 13) were found, without any occurrence of the recessive homozygote. Body fat reduction was initially confirmed compared to a control group which did not exercise ( n = 16; 29.1 ± 8.8 years), so that the exercise group obtained a reduction of -1.3 kg vs. -0.3 kg in the control group ( p = 0.03). When they were divided by genotype, there were significant changes in fat mass (-1.3 ± 2.1 kg; p = 0.00), lean mass (0.6 ± 1.5 kg; p = 0.02), fat percentage (-1.3 ± 1.6; p = 0.00), waist circumference (-2.2 ± 2.9 cm; p = 0.00), abdomen circumference (-3.3 ± 3.6 cm; p = 0.00) and hip circumference (-2.7 ± 2.7 cm; p = 0.00) for Pro/Pro genotypes; and fat mass (-1.1 ± 1.7 kg; p = 0.04), fat percentage (-0.9 ± 1.5; p = 0.04), abdomen circumference (-3.9 ± 3.5 cm; p = 0.00) and hip circumference (-1.8 ± 1.8 cm; p = 0.00) for Pro/Ala genotypes, without any group interaction differences. The Chi squared test revealed no differences in the distribution of responders or non-responders according to genotype. It is concluded that an aerobic training program promotes weight loss, but the Pro12Ala polymorphism in the PPARγ2 gene does not influence the variability of aerobic-induced exercise weight loss. (Copyright © 2020 Cardoso, Persuhn, Ribeiro, de Sousa, Sena, de Almeida, Modesto-Filho, da Silva and Silva.)
Databáze:	MEDLINE
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