Preparation and In Vitro Evaluation of Ibuprofen Spherical Agglomerates.
| Autor: | Ravouru N; Sri Padmavati Mahila Visvavidyalayam, (Women's University), Institute of Pharmaceutical Technology, Tirupati, Andhra Pradesh, India., Penjuri SCB; MNR College of Pharmacy, Department of Pharmaceutics, Sangareddy, Telangana, India., Damineni S; Sultan-ul-Uloom College of Pharmacy, Department of Pharmaceutics, Hyderabad, Telangana, India., Muni RL; Sri Padmavati Mahila Visvavidyalayam, (Women's University), Institute of Pharmaceutical Technology, Tirupati, Andhra Pradesh, India., Poreddy SR; MNR College of Pharmacy, Department of Pharmaceutics, Sangareddy, Telangana, India. |
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| Jazyk: | angličtina |
| Zdroj: | Turkish journal of pharmaceutical sciences [Turk J Pharm Sci] 2018 Apr; Vol. 15 (1), pp. 7-15. Date of Electronic Publication: 2018 Apr 02. |
| DOI: | 10.4274/tjps.09609 |
| Abstrakt: | Objectives: Ibuprofen, an anti-inflammatory drug, is characterized by poor water solubility, which limits its pharmacologic effects. The present work aimed to the study the effect of agglomeration on the micromeritic properties and dissolution of ibuprofen. Materials and Methods: Ibuprofen agglomerates were prepared by solvent change method using water, dichloromethane and DMSO as poor solvent, bridging liquid and good solvent respectively in the ratio of 57.5:12.5:30. Process variables such as amount of bridging liquid, mode of addition, temperature and stirring rate were optimized. Results: SEM studies indicate that agglomerates produced were spherical and exhibit irregular shape. X-Ray Powder Diffraction spectra revealed the absence of polymorphism. DSC spectra showed no change in melting point indicating absence of crystal modification. The agglomerates exhibited improved solubility, dissolution rate and micromeritic properties compared to pure drug. Conclusion: Anti-inflammatory studies were conducted in Wistar strain male albino rats and ibuprofen agglomerates showed more significant activity than the pure drug which may be due to better absorption. Ulcerogenic potential study was carried out for pure ibuprofen and agglomerates. Better ulcerogenic potential was observed in ibuprofen agglomerates treated rats. Competing Interests: Conflict of Interest: No conflict of interest was declared by the authors. (©Copyright 2018 Turk J Pharm Sci, Published by Galenos Publishing House.) |
| Databáze: | MEDLINE |
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