A molecular filter for the cnidarian stinging response.

Autor: Weir K; Department of Molecular and Cellular Biology, Harvard University, Cambridge, United States., Dupre C; Department of Molecular and Cellular Biology, Harvard University, Cambridge, United States., van Giesen L; Department of Molecular and Cellular Biology, Harvard University, Cambridge, United States., Lee AS; Department of Biology, Brandeis University, Waltham, United States., Bellono NW; Department of Molecular and Cellular Biology, Harvard University, Cambridge, United States.
Jazyk: angličtina
Zdroj: ELife [Elife] 2020 May 26; Vol. 9. Date of Electronic Publication: 2020 May 26.
DOI: 10.7554/eLife.57578
Abstrakt: All animals detect and integrate diverse environmental signals to mediate behavior. Cnidarians, including jellyfish and sea anemones, both detect and capture prey using stinging cells called nematocytes which fire a venom-covered barb via an unknown triggering mechanism. Here, we show that nematocytes from Nematostella vectensis use a specialized voltage-gated calcium channel (nCa V ) to distinguish salient sensory cues and control the explosive discharge response. Adaptations in nCa V confer unusually sensitive, voltage-dependent inactivation to inhibit responses to non-prey signals, such as mechanical water turbulence. Prey-derived chemosensory signals are synaptically transmitted to acutely relieve nCa V inactivation, enabling mechanosensitive-triggered predatory attack. These findings reveal a molecular basis for the cnidarian stinging response and highlight general principles by which single proteins integrate diverse signals to elicit discrete animal behaviors.
Competing Interests: KW, CD, Lv, AL, NB No competing interests declared
(© 2020, Weir et al.)
Databáze: MEDLINE
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