Temporal association of sNfL and gad-enhancing lesions in multiple sclerosis.

Autor: Rosso M; Harvard Medical School, Boston, Massachusetts, 02115, USA.; Ann Romney Center for Neurologic Disease, Harvard Medical School, Boston, Massachusetts, 02115, USA., Gonzalez CT; Harvard Medical School, Boston, Massachusetts, 02115, USA.; Ann Romney Center for Neurologic Disease, Harvard Medical School, Boston, Massachusetts, 02115, USA., Healy BC; Harvard Medical School, Boston, Massachusetts, 02115, USA.; Ann Romney Center for Neurologic Disease, Harvard Medical School, Boston, Massachusetts, 02115, USA.; Massachusetts General Hospital Biostatistics Center, Boston, Massachusetts, USA., Saxena S; Harvard Medical School, Boston, Massachusetts, 02115, USA.; Ann Romney Center for Neurologic Disease, Harvard Medical School, Boston, Massachusetts, 02115, USA., Paul A; Harvard Medical School, Boston, Massachusetts, 02115, USA.; Ann Romney Center for Neurologic Disease, Harvard Medical School, Boston, Massachusetts, 02115, USA., Bjornevik K; Department on Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Kuhle J; Departments of Medicine, Biomedicine and Clinical Research, Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Basel, Switzerland., Benkert P; Department of Clinical Research, Clinical Trial Unit, University Hospital Basel, University of Basel, Basel, Switzerland., Leppert D; Departments of Medicine, Biomedicine and Clinical Research, Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Basel, Switzerland., Guttmann C; Harvard Medical School, Boston, Massachusetts, 02115, USA.; Ann Romney Center for Neurologic Disease, Harvard Medical School, Boston, Massachusetts, 02115, USA., Bakshi R; Harvard Medical School, Boston, Massachusetts, 02115, USA.; Ann Romney Center for Neurologic Disease, Harvard Medical School, Boston, Massachusetts, 02115, USA.; Department of Neurology, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Boston, Massachusetts, USA., Weiner HL; Harvard Medical School, Boston, Massachusetts, 02115, USA.; Ann Romney Center for Neurologic Disease, Harvard Medical School, Boston, Massachusetts, 02115, USA.; Department of Neurology, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Boston, Massachusetts, USA., Chitnis T; Harvard Medical School, Boston, Massachusetts, 02115, USA.; Ann Romney Center for Neurologic Disease, Harvard Medical School, Boston, Massachusetts, 02115, USA.; Department of Neurology, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Jazyk: angličtina
Zdroj: Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2020 Jun; Vol. 7 (6), pp. 945-955. Date of Electronic Publication: 2020 May 25.
DOI: 10.1002/acn3.51060
Abstrakt: Objective: Multiple sclerosis (MS) is an autoimmune demyelinating disorder, which is characterized by relapses and remissions. Serum neurofilament light chain (sNfL) is an emerging biomarker of disease activity but its clinical use is still limited. In this study, we aim to characterize the temporal association between sNfL and new clinical relapses and new gadolinium-enhancing (Gd+) lesions.
Methods: Annual sNfL levels were measured with a single-molecule array (SIMOA) assay in 94 patients with MS enrolled in the Comprehensive Longitudinal Investigation of Multiple Sclerosis at the Brigham and Women's Hospital (CLIMB) study. We used a multivariable linear mixed-effects model to test the temporal association of sNfL with clinical relapses and/or new Gd+ lesions. We adjusted this model for age, disease duration, sex, and disease-modifying therapies (DMTs) use.
Results: In the 3 months after a Gd+ lesion, we observed an average 35% elevation in sNfL (P < 0.0001) compared to remission samples. We also observed an average 32.3% elevation in sNfL at the time of or prior to a Gd+ lesion (P = 0.002) compared to remission. We observed a significant elevation in sNfL after a clinical relapse only when associated with a Gd+ lesion.
Interpretation: Our findings support sNfL as a marker of clinical relapses and Gd+ lesions. sNfL peaks in a 3-month window around Gd+ lesions. sNfL shows promise as a biomarker of neurological inflammation and possibly of simultaneous Gd+ lesions during a clinical relapse.
(© 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.)
Databáze: MEDLINE
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