Trial for reduction of Ochratoxin A residues in fish feed by using nano particles of hydrated sodium aluminum silicates (NPsHSCAS) and copper oxide.

Autor: Fadl SE; Biochemistry Dep., Faculty of Veterinary Medicine - Matrouh University, Matrouh, Egypt. Electronic address: nourmallak@mau.edu.eg., El-Shenawy AM; Biochemistry, Nutritional Deficiency Diseases and Toxicology Unit, Animal Health Research Institute (ARC) - Kafrelsheikh, Egypt., Gad DM; Fish Diseases Unit, Animal Health Research Institute (ARC) - Kafrelsheikh, Egypt., El Daysty EM; Mycology and Mycotoxins Department, Animal Health Research Institute (ARC), Dokki, Egypt., El-Sheshtawy HS; Chemistry Department, Faculty of Science, Kafrelsheikh University, Egypt., Abdo WS; Pathology Dep., Faculty of Vet. Medicine, Kafrelsheikh University, Egypt.
Jazyk: angličtina
Zdroj: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2020 Sep; Vol. 184, pp. 1-9. Date of Electronic Publication: 2020 May 22.
DOI: 10.1016/j.toxicon.2020.05.014
Abstrakt: This paper was designed to analyze the effect of ochratoxin A (OTA) contaminated feed on the growth outcomes, certain serum biochemical, histopathology, and OTA residue in the dorsal muscle, liver, and kidney in Nile tilapia. Also, to improve the drastic effect of OTA through dietary supplementation of hydrated sodium aluminum silicates nanoparticles or nano copper. For performing the present study, 270 fish were randomly allotted into 6 equal groups according to ochratoxin and nanoparticles of hydrated sodium aluminum silicates or copper oxide. The results indicated that supplementation of two levels of both nanoparticles (aluminum silicate or copper) as a mycotoxin adsorbent could prevent ochratoxicosis in Nile tilapia fish. In addition, they maintained optimal growth performance, feed efficiency without bad effect on serum profiles and vital organs function of fish in a dose-dependent manner. Histopathologically, the most interesting finding was the precipitation of calcium salts known as nephrocalcinosis, within the tubules, upon the degenerative tubules and tunica intima and media of the blood vessels in the control positive group. These pathological lesions were mitigated by nanoparticle supplementation. Thus increase the safety of fish products.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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