Evolution of the Insecticide Target Rdl in African Anopheles Is Driven by Interspecific and Interkaryotypic Introgression.

Autor:	Grau-Bové X; Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Tomlinson S; Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.; Centre for Health Informatics, Computing and Statistics, Lancaster University, Lancaster, United Kingdom., O'Reilly AO; School of Biological and Environmental Sciences, Liverpool John Moores University, Liverpool, United Kingdom., Harding NJ; Big Data Institute, University of Oxford, Li Ka Shing Centre for Health Information and Discovery, Oxford, United Kingdom., Miles A; Big Data Institute, University of Oxford, Li Ka Shing Centre for Health Information and Discovery, Oxford, United Kingdom.; Wellcome Sanger Institute, Hinxton, United Kingdom., Kwiatkowski D; Big Data Institute, University of Oxford, Li Ka Shing Centre for Health Information and Discovery, Oxford, United Kingdom.; Wellcome Sanger Institute, Hinxton, United Kingdom., Donnelly MJ; Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.; Wellcome Sanger Institute, Hinxton, United Kingdom., Weetman D; Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Jazyk:	angličtina
Zdroj:	Molecular biology and evolution [Mol Biol Evol] 2020 Oct 01; Vol. 37 (10), pp. 2900-2917.
DOI:	10.1093/molbev/msaa128
Abstrakt:	The evolution of insecticide resistance mechanisms in natural populations of Anopheles malaria vectors is a major public health concern across Africa. Using genome sequence data, we study the evolution of resistance mutations in the resistance to dieldrin locus (Rdl), a GABA receptor targeted by several insecticides, but most notably by the long-discontinued cyclodiene, dieldrin. The two Rdl resistance mutations (296G and 296S) spread across West and Central African Anopheles via two independent hard selective sweeps that included likely compensatory nearby mutations, and were followed by a rare combination of introgression across species (from A. gambiae and A. arabiensis to A. coluzzii) and across nonconcordant karyotypes of the 2La chromosomal inversion. Rdl resistance evolved in the 1950s as the first known adaptation to a large-scale insecticide-based intervention, but the evolutionary lessons from this system highlight contemporary and future dangers for management strategies designed to combat development of resistance in malaria vectors. (© The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.)
Databáze:	MEDLINE
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