Thalamic and striato-pallidal volumes in schizophrenia patients and individuals at risk for psychosis: A multi-atlas segmentation study.

Autor: Takahashi T; Department of Neuropsychiatry, University of Toyama School of Medicine, Toyama, Japan. Electronic address: tsutomu@med.u-toyama.ac.jp., Tsugawa S; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan., Nakajima S; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan., Plitman E; Computational Brain Anatomy Laboratory, Cerebral Imaging Center, Douglas Institute, Verdun, QC, Canada; Department of Psychiatry, McGill University, Montreal, QC, Canada; Department of Biological and Biomedical Engineering, McGill University, Montreal, QC, Canada., Chakravarty MM; Computational Brain Anatomy Laboratory, Cerebral Imaging Center, Douglas Institute, Verdun, QC, Canada; Department of Psychiatry, McGill University, Montreal, QC, Canada; Department of Biological and Biomedical Engineering, McGill University, Montreal, QC, Canada., Masuda F; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan., Wada M; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan., Kurose S; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan., Ochi R; Faculty of Environment and Information Studies, Keio University, Tokyo, Japan., Matsushita K; Faculty of Environment and Information Studies, Keio University, Tokyo, Japan., Sasabayashi D; Department of Neuropsychiatry, University of Toyama School of Medicine, Toyama, Japan., Nakamura M; Department of Neuropsychiatry, University of Toyama School of Medicine, Toyama, Japan., Nishikawa Y; Department of Neuropsychiatry, University of Toyama School of Medicine, Toyama, Japan., Takayanagi Y; Department of Neuropsychiatry, University of Toyama School of Medicine, Toyama, Japan; Arisawabashi Hospital, Toyama, Japan., Nishiyama S; Department of Neuropsychiatry, University of Toyama School of Medicine, Toyama, Japan; Center for Health Care and Human Sciences, University of Toyama, Toyama, Japan., Higuchi Y; Department of Neuropsychiatry, University of Toyama School of Medicine, Toyama, Japan., Mizukami Y; Department of Neuropsychiatry, University of Toyama School of Medicine, Toyama, Japan., Furuichi A; Department of Neuropsychiatry, University of Toyama School of Medicine, Toyama, Japan., Kido M; Department of Neuropsychiatry, University of Toyama School of Medicine, Toyama, Japan., Hashimoto R; Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan; Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Japan., Noguchi K; Department of Radiology, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan., Fujii S; Faculty of Environment and Information Studies, Keio University, Tokyo, Japan., Mimura M; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan., Noda Y; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan., Suzuki M; Department of Neuropsychiatry, University of Toyama School of Medicine, Toyama, Japan.
Jazyk: angličtina
Zdroj: Schizophrenia research [Schizophr Res] 2022 May; Vol. 243, pp. 268-275. Date of Electronic Publication: 2020 May 21.
DOI: 10.1016/j.schres.2020.04.016
Abstrakt: Despite previous neuroimaging studies demonstrating morphological abnormalities of the thalamus and other subcortical structures in patients with schizophrenia, the potential role of the thalamus and its subdivisions in the pathophysiology of this illness remains elusive. It is also unclear whether similar changes of these structures occur in individuals at high risk for psychosis. In this study, magnetic resonance imaging was employed with the Multiple Automatically Generated Templates (MAGeT) brain segmentation algorithm to determine volumes of the thalamic subdivisions, the striatum (caudate, putamen, and nucleus accumbens), and the globus pallidus in 62 patients with schizophrenia, 38 individuals with an at-risk mental state (ARMS) [4 of whom (10.5%) subsequently developed schizophrenia], and 61 healthy subjects. Cognitive function of the patients was assessed by using the Brief Assessment of Cognition in Schizophrenia (BACS) and the Schizophrenia Cognition Rating Scale (SCoRS). Thalamic volume (particularly the medial dorsal and ventral lateral nuclei) was smaller in the schizophrenia group than the ARMS and control groups, while there were no differences for the striatum and globus pallidus. In the schizophrenia group, the reduction of thalamic ventral lateral nucleus volume was significantly associated with lower BACS score. The pallidal volume was positively correlated with the dose of antipsychotic treatment in the schizophrenia group. These results suggest that patients with schizophrenia, but not those with ARMS, exhibit volume reduction in specific thalamic subdivisions, which may underlie core clinical features of this illness.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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