Auditory versus visual neuroscience-informed cognitive training in schizophrenia: Effects on cognition, symptoms and quality of life.

Autor: Scoriels L; Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Brazil; Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Brazil; Department of Psychiatry, University of Cambridge, United Kingdom., Genaro LT; Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Brazil; Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Brazil., Mororó LGC; Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Brazil; Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Brazil., Keffer S; Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Brazil; Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Brazil., Guimarães ALDV; Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Brazil; Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Brazil., Ribeiro PVS; Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Brazil; Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Brazil., Tannos FM; Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Brazil; Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Brazil., Novaes C; Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Brazil; Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Brazil., França AI; Faculdade de Letras, Universidade Federal do Rio de Janeiro, Brazil., Goldenstein N; Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Brazil., Sahakian BJ; Department of Psychiatry, University of Cambridge, United Kingdom., Cavalcanti MT; Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Brazil., Fisher M; Department of Psychiatry, University of Minnesota, United States., Vinogradov S; Department of Psychiatry, University of Minnesota, United States., Panizzutti R; Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Brazil; Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Brazil. Electronic address: rogerio@icb.ufrj.br.
Jazyk: angličtina
Zdroj: Schizophrenia research [Schizophr Res] 2020 Aug; Vol. 222, pp. 319-326. Date of Electronic Publication: 2020 May 21.
DOI: 10.1016/j.schres.2020.05.017
Abstrakt: Background: Cognitive impairments are related to deficits in primary auditory and visual sensory processes in schizophrenia. These impairments can be remediated by neuroscience-informed computerized cognitive trainings that target auditory and visual processes. However, it is not clear which modality results in greater improvements in cognition, symptoms and quality of life. We aimed to investigate the impact of training auditory versus visual cognitive processes in global cognition in patients with schizophrenia.
Methods: Seventy-nine schizophrenia participants were randomly assigned to either 40 h of auditory or visual computerized training. Auditory and visual exercises were chosen to be dynamically equivalent and difficulties increased progressively during the training. We evaluated cognition, symptoms and quality of life before, after 20 h, and after 40 h of training. ClinicalTrials.gov (1R03TW009002-01).
Results: Participants who received the visual training showed significant improvements in global cognition compared to the auditory training group. The visual training significantly improved attention and reasoning and problem-solving, while the auditory training improved reasoning and problem-solving only. Schizophrenia symptoms improved after training in both groups, whereas quality of life remained unchanged. Interestingly, there was a significant and positive correlation between improvements in attention and symptoms in the visual training group.
Conclusions: We conclude that the visual training and the auditory training are differentially efficient at remediating cognitive deficits and symptoms of clinically stable schizophrenia patients. Ongoing follow-up of participants will evaluate the durability of training effects on cognition and symptoms, as well as the potential impact on quality of life over time.
Competing Interests: Declaration of competing interest Dr. Panizzutti is the founder of NeuroForma LTDA, a company with a financial interest in cognitive training. The remaining authors have no conflict of interest to disclose.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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