No Adaptation of the Prion Strain in a Heterozygous Case of Variant Creutzfeldt-Jakob Disease.

Autor: Boyle A, Plinston C, Laing F, Mackenzie G, Will RG, Manson JC, Diack AB
Jazyk: angličtina
Zdroj: Emerging infectious diseases [Emerg Infect Dis] 2020 Jun; Vol. 26 (6), pp. 1300-1303.
DOI: 10.3201/eid2606.191116
Abstrakt: We investigated a clinical case of variant Creutzfeldt-Jakob Disease in a person heterozygous for methionine/valine at codon 129 of the prion protein gene and identified the same strain properties in variant Creutzfeldt-Jakob disease in methionine homozygous persons and in bovine spongiform encephalopathy. These results indicate no adaptation of the agent in a different genetic background.
Databáze: MEDLINE