Urinary symptoms and quality of life in women living with HIV: a cross-sectional study.

Autor: Larouche M; Department of Obstetrics and Gynecology, McGill University, Montreal, QC, Canada. ml.larouche@mcgill.ca.; St. Mary's Research Centre, St. Mary's Hospital, Hayes Pavilion, room 4729, 3830 Lacombe, Montreal, Quebec, H3T 1M5, Canada. ml.larouche@mcgill.ca., Albert AYK; Women's Health Research Institute, Vancouver, BC, Canada., Lipsky N; Women's Health Research Institute, Vancouver, BC, Canada., Walmsley S; Department of Infectious Diseases, Toronto General Hospital, Toronto, ON, Canada., Loutfy M; Department of Infectious Diseases, Women's College Hospital, Toronto, ON, Canada., Smaill F; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada., Trottier S; Department of Microbiology, Infectious Diseases and Immunology, CHUQ/CHUL, Quebec, QC, Canada., Bitnun A; Department of Infectious Diseases, SickKids, Toronto, ON, Canada., Yudin MH; Department of Obstetrics and Gynecology & Reproductive Infectious Diseases, St. Michael's Hospital, Toronto, ON, Canada., Cundiff GW; Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada., Money DM; Women's Health Research Institute, Vancouver, BC, Canada.; Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada.
Jazyk: angličtina
Zdroj: International urogynecology journal [Int Urogynecol J] 2021 Feb; Vol. 32 (2), pp. 353-358. Date of Electronic Publication: 2020 May 22.
DOI: 10.1007/s00192-020-04343-z
Abstrakt: Introduction and Hypothesis: To determine prevalence and quality of life impact of lower urinary tract symptoms (LUTS) in women living with HIV (WLWH).
Methods: Cross-sectional urinary questionnaires were included in a multicenter national prospective study of the HPV vaccine in WLWH. Demographic and clinical information was abstracted from the parent study. The Urinary Distress Inventory (UDI-6) and Urinary Impact Questionnaire (UIQ-7) were administered. Wilcoxon rank sum, two-sample chi-square or Fisher's exact tests were used as appropriate to compare women with UDI-6 score ≥ 25 to those with lower UDI-6 scores on demographic and HIV-related factors. Significant categorical variables were followed up with logistic regression to estimate odds ratios (OR).
Results: One hundred seventy-seven women completed urinary questionnaires (85.5% of cohort). Median age was 44.1 (37.2-50.6). Mean CD4 count was 621 (410-785), and 132 women (74.6%) were virologically suppressed. Median UDI-6 score was 4.2 (0-25). Fifty-one women (28.8%) had a UIQ-7 score > 0. Among those with a UDI-6 score of at least 25, median UIQ-7 was 9.5 (0-47.6). UDI-6 ≥ 25 was significantly associated with increasing age, higher BMI, Canada as country of origin, peri-/postmenopausal status (OR 3.37, 95% CI = 1.71 to 6.75) and being parous (OR 2.92, 95% CI = 1.27 to 7.59) (all p < 0.05). HIV-related factors were not associated with UDI-6 ≥ 25.
Conclusions: LUTS were common, but we did not demonstrate a negative impact on quality of life in this sample of WLWH. Large comparative studies are needed to determine whether HIV is a risk factor for bothersome LUTS in women.
Databáze: MEDLINE
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