Thyroxine impregnated chitosan-based dressings stimulate angiogenesis and support fast wounds healing in rats: Potential clinical candidates.

Autor: Shahzadi L; Interdisciplinary Research Center in Biomedical Materials, COMSATS University Islamabad, Lahore Campus, 54000, Pakistan; Australian Centre for Research on Separation Science, Chemistry, School of Natural Science, University of Tasmania, Hobart, Tasmania, Australia., Bashir M; Department of Plastic, Reconstructive surgery and Burn Unit, King Edward Medical University Lahore, 54000, Pakistan., Tehseen S; Interdisciplinary Research Center in Biomedical Materials, COMSATS University Islamabad, Lahore Campus, 54000, Pakistan., Zehra M; National Center of Excellence in Molecular Biology (CEMB), University of the Punjab, 53700 Lahore, Pakistan., Mehmood A; National Center of Excellence in Molecular Biology (CEMB), University of the Punjab, 53700 Lahore, Pakistan., Chaudhry AA; Interdisciplinary Research Center in Biomedical Materials, COMSATS University Islamabad, Lahore Campus, 54000, Pakistan., Rehman IU; Interdisciplinary Research Center in Biomedical Materials, COMSATS University Islamabad, Lahore Campus, 54000, Pakistan; Engineering Department, Lancaster University, Lancaster, UK., Yar M; Interdisciplinary Research Center in Biomedical Materials, COMSATS University Islamabad, Lahore Campus, 54000, Pakistan. Electronic address: drmyar@cuilahore.edu.pk.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2020 Oct 01; Vol. 160, pp. 296-306. Date of Electronic Publication: 2020 May 19.
DOI: 10.1016/j.ijbiomac.2020.05.127
Abstrakt: This research paper demonstrates efficacy of chitosan and thyroxine loaded chitosan (CS) dressings for their angiogenic and wound healing potential. The dressings were prepared by freeze gelation method. Thyroxine was loaded by physical adsorption into chitosan membranes. The porosity was analyzed by scanning electron microscopy (SEM) and chemical structures were investigated by Fourier transform infra-red spectroscopy (FTIR). Cell culture studies showed materials were non-toxic and chorioallantoic membranes assay (CAM) confirmed that the thyroxine loaded chitosan stimulated angiogenesis much higher than simple chitosan dressings. In addition, thyroxine loaded dressings showed excellent wound healing potential when tested on full thickness rats wounds. A good epithelialization was obtained along with robust wound closure. Overall, as compared to chitosan, thyroxine containing membranes showed high level of angiogenesis and fast wound healing.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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