Two-Phase Dibromocyclopropanation of Unsaturated Alcohols Using Flow Chemistry.

Autor: Østby RB; Faculty of Engineering, Østfold University College, P.O. Box 700, NO-1757 Halden, Norway., Didriksen T; SINTEF Industry, P.O. Box 124 Blindern, NO-0314 Oslo, Norway., Antonsen SG; Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, P.O. Box 5003, NO-1432 Ås, Norway., Nicolaisen SS; Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, P.O. Box 5003, NO-1432 Ås, Norway., Stenstrøm Y; Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, P.O. Box 5003, NO-1432 Ås, Norway.
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2020 May 19; Vol. 25 (10). Date of Electronic Publication: 2020 May 19.
DOI: 10.3390/molecules25102364
Abstrakt: Dibromocyclopropanations are conventionally done by addition of dibromocarbene to alkenes under phase-transfer conditions in batch reactions using a strong base (50% NaOH (aq)), vigorous stirring and long reaction times. We have shown that cyclopropanation of unsaturated alcohols can be done under ambient conditions using continuous flow chemistry with 40% ( w / w ) NaOH (aq) as the base. The reactions were generally rapid; the yields were comparable to yields reported in the literature for the conventional batch reaction.
Databáze: MEDLINE
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