| Autor: |
Tibbo AJ; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Baillie GS; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, UK. |
| Jazyk: |
angličtina |
| Zdroj: |
Cells [Cells] 2020 May 19; Vol. 9 (5). Date of Electronic Publication: 2020 May 19. |
| DOI: |
10.3390/cells9051254 |
| Abstrakt: |
Phosphodiesterases (PDEs) are the only superfamily of enzymes that have the ability to break down cyclic nucleotides and, as such, they have a pivotal role in neurological disease and brain development. PDEs have a modular structure that allows targeting of individual isoforms to discrete brain locations and it is often the location of a PDE that shapes its cellular function. Many of the eleven different families of PDEs have been associated with specific diseases. However, we evaluate the evidence, which suggests the activity from a sub-family of the PDE4 family, namely PDE4B, underpins a range of important functions in the brain that positions the PDE4B enzymes as a therapeutic target for a diverse collection of indications, such as, schizophrenia, neuroinflammation, and cognitive function. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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