Immune response and onset of protection from Bovine viral diarrhea virus 2 infection induced by modified-live virus vaccination concurrent with injectable trace minerals administration in newly received beef calves.

Autor: Bittar JHJ; Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA, 30602-2771, United States; Group for Reproduction in Animals, Vaccinology and Infectious Diseases (GRAVID(TM)), United States; Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, 32610, United States., Palomares RA; Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA, 30602-2771, United States; Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA, 30602-2771, United States; Group for Reproduction in Animals, Vaccinology and Infectious Diseases (GRAVID(TM)), United States. Electronic address: palomnr@uga.edu., Hurley DJ; Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA, 30602-2771, United States; Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA, 30602-2771, United States., Hoyos-Jaramillo A; Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA, 30602-2771, United States; Group for Reproduction in Animals, Vaccinology and Infectious Diseases (GRAVID(TM)), United States., Rodriguez A; Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA, 30602-2771, United States; Group for Reproduction in Animals, Vaccinology and Infectious Diseases (GRAVID(TM)), United States., Stoskute A; Group for Reproduction in Animals, Vaccinology and Infectious Diseases (GRAVID(TM)), United States., Hamrick B; Group for Reproduction in Animals, Vaccinology and Infectious Diseases (GRAVID(TM)), United States., Norton N; Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA, 30602-2771, United States., Adkins M; Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA, 30602-2771, United States., Saliki JT; Athens Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, Athens, GA, 30602-2771, United States., Sanchez S; Athens Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, Athens, GA, 30602-2771, United States., Lauber K; Group for Reproduction in Animals, Vaccinology and Infectious Diseases (GRAVID(TM)), United States.
Jazyk: angličtina
Zdroj: Veterinary immunology and immunopathology [Vet Immunol Immunopathol] 2020 Jul; Vol. 225, pp. 110055. Date of Electronic Publication: 2020 Apr 27.
DOI: 10.1016/j.vetimm.2020.110055
Abstrakt: Strategies to improve the onset of protective immunity induced by vaccination against respiratory pathogens may have a significant impact on health of newly received beef calves. The objective was to determine if the use of injectable trace minerals (ITM; Se, Zn, Cu, and Mn) concurrent with a modified-live virus (MLV) vaccine enhances the immune response and onset of protection in beef calves challenged with BVDV2 five days after vaccination. Forty-five calves were randomly assigned to one of three groups (15/group): VAC + ITM, received MLV-vaccine and ITM (Multimin®90) subcutaneously (SC); VAC + SAL, received the same vaccine and saline SC; or UNVAC, unvaccinated. Five days after vaccination (d.0), calves were challenged with BVDV2 strain 890. Health status was evaluated and blood samples were collected for leukocyte counts, BVDV1 and 2 serum neutralizing antibodies (SNA), BVDV-PCR, and percentage of CD4 + , CD8 + , WC1 + and CD25 + T-cells. VAC + ITM had lower health scores than UNVAC (d.8 and 9). VAC + ITM had higher BVDV1 & 2 SNA titers than VAC + SAL and UNVAC on d.21 and 28. Lymphocyte counts decreased in UNVAC but not in VAC + ITM or VAC + SAL (d.3 to 11). CD4 + T-cells significantly decreased in UNVAC and VAC + SAL (d.3). VAC + ITM had higher percentage of CD4 + T-cells than UNVAC (d.3 and 7). VAC + ITM had lower percentage of activated CD4 + and CD8 + T-cells than UNVAC (d.7). In summary, vaccination induced a rapid protection against BVDV2 infection. Administration of ITM was associated with increased SNA response to BVDV1 & 2, enhanced health status, mitigation of CD4 + T-cells decrease, and reduction of T-cell activation in calves challenged with BVDV2 five days after immunization. These results support the strategic use of ITM concurrent with vaccination, especially when a rapid protection is needed in newly received beef calves.
Competing Interests: Declaration of Competing Interest The authors of this article, declare that there are no conflicts of interest.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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