A social encounter drives gene expression changes linked to neuronal function, brain development, and related disorders in mice expressing the serotonin transporter Ala56 variant.

Autor: O'Reilly KC; Department of Psychiatry, Columbia University, New York State Psychiatric Institute, 1051 Riverside Dr, Unit 78, New York, NY 10032, United States. Electronic address: kally.sparks@nyspi.columbia.edu., Anacker AMJ; Department of Psychiatry, Columbia University, New York State Psychiatric Institute, 1051 Riverside Dr, Unit 78, New York, NY 10032, United States. Electronic address: allison.anacker@gmail.com., Rogers TD; Middle Tennessee State University, Department of Psychology, 355 Jones Hall, 624 Old Main Circle, Murfreesboro, TN 37132, United States; Vanderbilt University, Nashville, TN 37232, United States. Electronic address: tiffanydrogers@gmail.com., Forsberg CG; Department of Radiology, Medical University of South Carolina, Charleston, SC 29425, United States; Vanderbilt University, Nashville, TN 37232, United States. Electronic address: forsbeca@musc.edu., Wang J; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, United States; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, United States; Vanderbilt University, Nashville, TN 37232, United States. Electronic address: jingwang.uestc@gmail.com., Zhang B; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, United States; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, United States; Vanderbilt University, Nashville, TN 37232, United States. Electronic address: bing.zhang@bcm.edu., Blakely RD; Brain Institute and Department of Biomedical Science, Florida Atlantic University, Jupiter, FL 33458, United States; Vanderbilt University, Nashville, TN 37232, United States. Electronic address: rblakely@health.fau.edu., Veenstra-VanderWeele J; Department of Psychiatry, Columbia University, New York State Psychiatric Institute, 1051 Riverside Dr, Unit 78, New York, NY 10032, United States; Vanderbilt University, Nashville, TN 37232, United States. Electronic address: jeremy.veenstra@nyspi.columbia.edu.
Jazyk: angličtina
Zdroj: Neuroscience letters [Neurosci Lett] 2020 Jun 21; Vol. 730, pp. 135027. Date of Electronic Publication: 2020 May 11.
DOI: 10.1016/j.neulet.2020.135027
Abstrakt: Multiple lines of evidence implicate the serotonin (5-HT) system in social function, including biomarker findings in autism spectrum disorder. In mice, knock-in of a rare Gly56Ala substitution in the serotonin transporter (SERT) causes elevated whole blood 5-HT levels, increased 5-HT clearance in the brain, and altered social and repetitive behavior. To further examine the molecular impact of this variant on social response, SERT Ala56 mutant mice and wildtype littermate controls were exposed to a social or non-social stimulus. We examined the differential activation of the prefrontal cortex, lateral amygdala, and medial amygdala, to social stimuli through RNA sequencing. Differentially expressed genes were enriched in axonal guidance signaling pathways, networks related to nervous system development and function, neurological and psychiatric disorders, and behavior. These identified pathways and networks may shed light on the molecular cascades underlying the impact of altered SERT function on social behavior.
Competing Interests: Declaration of Competing Interest All other authors declare no competing interests.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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