Total Synthesis of Benzofuran-Based Aspergillusene B via Halogenative Aromatization of Enones.
| Autor: | Grabovyi GA; Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607, United States., Bhatti A; Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607, United States., Mohr JT; Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607, United States. |
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| Jazyk: | angličtina |
| Zdroj: | Organic letters [Org Lett] 2020 Jun 05; Vol. 22 (11), pp. 4196-4200. Date of Electronic Publication: 2020 May 21. |
| DOI: | 10.1021/acs.orglett.0c01259 |
| Abstrakt: | A novel "non-aromatic pool" synthetic strategy for the synthesis of benzofuran-based natural products via oxidative haloaromatization of enones is reported. This approach is successfully applied in the first total synthesis of the natural product aspergillusene B. In comparison with a separately executed "aromatic pool" synthesis, the "non-aromatic pool" protocol demonstrates equivalent efficiency but offers a much higher degree of modularity. |
| Databáze: | MEDLINE |
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