Evaluation of thiol/disulfide homeostasis in patients with gestational diabetes mellitus.

Autor: Cakina S; Health Service Vocational College, Canakkale 18 Mart University, Canakkale, Turkey., Aydın B; Faculty of Medicine, Department of Obstetrics and Gynecology, Canakkale 18 Mart University, Canakkale, Turkey., Beyazit F; Faculty of Medicine, Department of Obstetrics and Gynecology, Canakkale 18 Mart University, Canakkale, Turkey.
Jazyk: angličtina
Zdroj: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2020 Nov; Vol. 36 (11), pp. 1006-1009. Date of Electronic Publication: 2020 May 21.
DOI: 10.1080/09513590.2020.1769062
Abstrakt: This study aimed to study the dynamic thiol/disulfide homeostasis in pregnant women with gestational diabetes mellitus (GDM). Forty-five pregnant women with GDM and 45 age-matched healthy pregnancies were included in this study. Thiol/disulfide homeostasis was measured using a commercial kit (Rel Assay Diagnostics). The patients with GDM had significantly higher disulfide concentrations than healthy pregnant patients ( p  = .001). Besides, the GDM group had significantly higher disulfide/total thiol, disüplhide/native thiol, and native thiol/total thiol ratio than healthy pregnant patients ( p  = .001, p  = .001 and p  = .001, respectively). The significantly higher concentrations of disulfide, disulfide/total thiol, disüplhide/native thiol, and native thiol/total thiol ratio in women with GDM could be considered as the increased oxidative stress.
Databáze: MEDLINE
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