A classification framework for Bacillus anthracis defined by global genomic structure.

Autor: Bruce SA; Department of Biological Sciences University at Albany - State University of New York Albany NY USA., Schiraldi NJ; Department of Information Technology Services University at Albany - State University of New York Albany NY USA., Kamath PL; School of Food and Agriculture University of Maine Orono ME USA., Easterday WR; Centre for Ecological and Evolutionary Synthesis Department of Biosciences University of Oslo Oslo Norway., Turner WC; Department of Biological Sciences University at Albany - State University of New York Albany NY USA.
Jazyk: angličtina
Zdroj: Evolutionary applications [Evol Appl] 2020 Jan 23; Vol. 13 (5), pp. 935-944. Date of Electronic Publication: 2020 Jan 23 (Print Publication: 2020).
DOI: 10.1111/eva.12911
Abstrakt: Bacillus anthracis , the causative agent of anthrax, is a considerable global health threat affecting wildlife, livestock, and the general public. In this study, whole-genome sequence analysis of over 350 B. anthracis isolates was used to establish a new high-resolution global genotyping framework that is both biogeographically informative and compatible with multiple genomic assays. The data presented in this study shed new light on the diverse global dissemination of this species and indicate that many lineages may be uniquely suited to the geographic regions in which they are found. In addition, we demonstrate that plasmid genomic structure for this species is largely consistent with chromosomal population structure, suggesting vertical inheritance in this bacterium has contributed to its evolutionary persistence. This classification methodology is the first based on population genomic structure for this species and has potential use for local and broader institutions seeking to understand both disease outbreak origins and recent introductions. In addition, we provide access to a newly developed genotyping script as well as the full whole-genome sequence analyses output for this study, allowing future studies to rapidly employ and append their data in the context of this global collection. This framework may act as a powerful tool for public health agencies, wildlife disease laboratories, and researchers seeking to utilize and expand this classification scheme for further investigations into B. anthracis evolution.
Competing Interests: None declared.
(© 2019 The Authors. Evolutionary Applications published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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