Epidemiology of Schistosomiasis and Soil-Transmitted Helminth Coinfections among Schoolchildren Living in Lambaréné, Gabon.

Autor:	Dejon-Agobé JC; 1Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.; 2Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Amsterdam University Medical Centers, location AMC, University of Amsterdam, Amsterdam, The Netherlands., Honkpehedji YJ; 1Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.; 3Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands., Zinsou JF; 1Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.; 3Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands., Edoa JR; 1Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon., Adégbitè BR; 1Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon., Mangaboula A; 1Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon., Agnandji ST; 1Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.; 4Institut für Tropenmedizin, Eberhad Karls Universität Tübingen, Tübingen, Germany., Mombo-Ngoma G; 1Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.; 4Institut für Tropenmedizin, Eberhad Karls Universität Tübingen, Tübingen, Germany.; 5I. Department of Medicine, Bernhard Nocht Institute for Tropical Medicine, University Medical Centre-Hamburg-Eppendorf, Hamburg, Germany., Ramharter M; 1Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.; 5I. Department of Medicine, Bernhard Nocht Institute for Tropical Medicine, University Medical Centre-Hamburg-Eppendorf, Hamburg, Germany., Kremsner PG; 1Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.; 4Institut für Tropenmedizin, Eberhad Karls Universität Tübingen, Tübingen, Germany.; 6German Center for Infection Research (DZIF), African Partner Institution, CERMEL, Lambaréné, Gabon.; 7German Center for Infection Research (DZIF), Partner Site, Tübingen, Germany., Lell B; 1Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.; 8Division of Infectious Diseases and Tropical Medicine, Department of Medicine 1, Medical University of Vienna, Vienna, Austria., Grobusch MP; 1Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.; 2Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Amsterdam University Medical Centers, location AMC, University of Amsterdam, Amsterdam, The Netherlands.; 4Institut für Tropenmedizin, Eberhad Karls Universität Tübingen, Tübingen, Germany., Adegnika AA; 1Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.; 3Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands.; 4Institut für Tropenmedizin, Eberhad Karls Universität Tübingen, Tübingen, Germany.; 6German Center for Infection Research (DZIF), African Partner Institution, CERMEL, Lambaréné, Gabon.; 7German Center for Infection Research (DZIF), Partner Site, Tübingen, Germany.
Jazyk:	angličtina
Zdroj:	The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2020 Jul; Vol. 103 (1), pp. 325-333. Date of Electronic Publication: 2020 May 14.
DOI:	10.4269/ajtmh.19-0835
Abstrakt:	Schistosomiasis is a parasitic infection highly prevalent in Central Africa where it is co-endemic with many other parasitic infections, including soil-transmitted helminths (STHs). For its optimal control, there is a need of descriptive epidemiological data for each endemic region. The objective of the present study was to determine the epidemiological situation around schistosomiasis in Lambaréné, Gabon. A cross-sectional study was conducted among schoolchildren. One urine sample per day was collected on three consecutive days for the diagnosis of schistosomiasis using a urine filtration technique. One stool sample was collected for the detection of Schistosoma spp. and STH spp. eggs using the Kato-Katz technique, and for larvae, using the coproculture technique. A total of 614 schoolchildren were included in the analysis. The overall prevalence of schistosomiasis and STH infections was 26% (159/614) and 15% (70/473), respectively. Human-freshwater contact was the main risk factor for schistosomiasis in the area (relative risk (RR) = 2.96 [2.20-4.00], P < 0.001). Hematuria (RR = 5.53 [4.30-7.10], P < 0.001) and proteinuria (RR = 2.12 [1.63-2.75], P < 0.001) as well as infection with Trichuris trichiura (RR = 1.86 [1.33-2.61], P = 0.002) and Ascaris lumbricoides (RR = 1.96 [1.19-3.21], P = 0.039) were associated with an increased risk of schistosomiasis. Trichuris trichiura was the highest prevalent STH species in the area. Our study reports a moderate prevalence for schistosomiasis with human-water contact as the main risk factor, whereas the prevalence of STH infections appears to be low. Our results stress the need for the implementation of WHO recommendations for schistosomiasis control.
Databáze:	MEDLINE
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