Low back pain in athletes can be controlled with acupuncture by a catecholaminergic pathway: clinical trial.

Autor: Arriaga-Pizano L; Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades del Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Ciudad de México, Mexico., Gómez-Jiménez DC; Escuela Nacional de Medicina y Homeopatía, Instituto Politécnico Nacional, Ciudad de México, México., Flores-Mejía LA; Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades del Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Ciudad de México, Mexico., Pérez-Cervera Y; 'Laboratorio de Inmunología, Centro de Estudios en Ciencias de la Salud y la Enfermedad, Facultad de Odontología, Universidad Autónoma 'Benito Juárez' de Oaxaca, Oaxaca, México.; Centro de Investigación UNAM-UABJO, Facultad de Medicina y Cirugía, Universidad Autónoma 'Benito Juárez' de Oaxaca, Oaxaca, México., Solórzano-Mata CJ; 'Laboratorio de Inmunología, Centro de Estudios en Ciencias de la Salud y la Enfermedad, Facultad de Odontología, Universidad Autónoma 'Benito Juárez' de Oaxaca, Oaxaca, México.; Centro de Investigación UNAM-UABJO, Facultad de Medicina y Cirugía, Universidad Autónoma 'Benito Juárez' de Oaxaca, Oaxaca, México., López-Macías C; Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades del Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Ciudad de México, Mexico., Isibasi A; Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades del Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Ciudad de México, Mexico., Torres-Rosas R; 'Laboratorio de Inmunología, Centro de Estudios en Ciencias de la Salud y la Enfermedad, Facultad de Odontología, Universidad Autónoma 'Benito Juárez' de Oaxaca, Oaxaca, México.
Jazyk: angličtina
Zdroj: Acupuncture in medicine : journal of the British Medical Acupuncture Society [Acupunct Med] 2020 Dec; Vol. 38 (6), pp. 388-395. Date of Electronic Publication: 2020 May 20.
DOI: 10.1177/0964528420912251
Abstrakt: Background: Activation of the sympathetic nervous system attenuates inflammation via catecholamines. Recent evidence has shown that electroacupuncture (EA) activates neuronal networks involved in the release of dopamine and norepinephrine that control systemic inflammation. In muscle, catecholamines are related to cyclic adenosine monophosphate (cAMP). This signaling molecule has been implicated in recovery from sustained contractile activity, which may induce muscular pain, such as that which occurs during low back pain (LBP).
Objective: Our aim was to evaluate the effects of EA used for the control of LBP on the activation of the sympathetic nervous system in a randomized controlled clinical trial in athletes.
Methods: Two groups of athletes with acute or chronic low back pain were studied. EA, sham EA and pharmacological treatment (diclofenac sodium) were evaluated. The outcome measures included a pain score represented by a visual analogue scale (VAS) and serum levels of catecholamines quantified by enzyme-linked immunosorbent assay. In addition, blood was collected into chilled heparin tubes, placed in 96-well cell culture plates and incubated with an equal volume of Roswell Park Memorial Institute (RPMI) medium, with lipopolysaccharide (LPS) alone or with catecholamines. Tumor necrosis factor (TNF)-α levels in the supernatants were analyzed.
Results: The results indicated that the initial pain ratings did not differ between the groups analyzed. EA induced epinephrine secretion but not norepinephrine or dopamine secretion. Although EA and pharmacological treatment did not differ in terms of pain relief, in vitro epinephrine and norepinephrine reduced TNF-α production in response to LPS stimuli.
Conclusion: EA activates the sympathetic nervous system and induces the release of epinephrine, which could ameliorate inflammation and protect muscular tissue in addition to relieving pain.
Databáze: MEDLINE
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