Chemical profile and therapeutic potentials of Xylocarpus moluccensis (Lam.) M. Roem.: A literature-based review.

Autor: Islam MT; Laboratory of Theoretical and Computational Biophysics, Ton Duc Thang University, Ho Chi Minh City, 700000, Viet Nam; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, 700000, Viet Nam. Electronic address: muhammad.torequl.islam@tdtu.edu.vn., Sharifi-Rad J; Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: javad.sharifirad@gmail.com., Martorell M; Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, 4070386, Concepción, Chile; Universidad de Concepción, Unidad de Desarrollo Tecnológico, UDT, Concepción, 4070386, Chile. Electronic address: martorellpons@gmail.com., Ali ES; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 303 E Superior St, Chicago, IL, 60611, USA. Electronic address: eunus2ali@yahoo.com., Asghar MN; Department of Medical Biology, University of Quebec, Trois Riveres, Canada. Electronic address: Muhammad.Nadeem.Asghar2@uqtr.ca., Deeba F; Basic Sciences Department, College of Science and Health Professions-Jeddah, King Saud Bin Abdul-Aziz University for Health Science, Ministry of National Guard Health Affairs, Jeddah, 21423, Saudi Arabia. Electronic address: DeebaFA@NGHA.MED.SA., Firoz CK; Department of Medical Laboratory Technology, Institute of Paramedical Sciences, MES Medical College, Kerala, India. Electronic address: ckfiroz@gmail.com., Mubarak MS; Department of Chemistry, The University of Jordan, Amman, 11942, Jordan. Electronic address: mmubarak@ju.edu.jo.
Jazyk: angličtina
Zdroj: Journal of ethnopharmacology [J Ethnopharmacol] 2020 Sep 15; Vol. 259, pp. 112958. Date of Electronic Publication: 2020 May 16.
DOI: 10.1016/j.jep.2020.112958
Abstrakt: Ethnopharmacological Relevance: Historically, mangrove plants are among the potential sources of foods and remedies for humans living in the forests and nearby communities. Xylocarpus moluccensis (Lam.) M. Roem., an important mangrove medicinal plant, has been traditionally used for many purposes such as treatment of fever, dysentery, diarrhea, swelling, and abdominal disorders. The aim of the present work was to summarize the chemical reports and biological activities of the mangrove medicinal plant X. moluccensis based on information collected from different databases.
Materials and Methods: An up-to-date search (till Aug 2019) was carried out in databases such as PubMed, Science Direct, Google Scholar, and various patient offices (e.g., WIPO, CIPO, USPTO) using the keywords: 'Xylocarpus moluccensis', and/or paired with 'ethnobotanical use', and 'phytochemical'. In vitro, ex vivo, or in vivo studies were included.
Results: Findings suggest that X. moluccensis contains various important minerals and phytochemicals, where flavonoids, terpenes and terpenoids are the most prominent isolated phyto-constituents of X. moluccensis. Extracts/fractions or isolated compounds from this plant possess diverse biological activities, including anti-inflammatory, anti-microbial, antineoplastic, anti-diarrheal, insecticidal, anti-feedant, neuropharmacological (e.g., central nervous system depressant), anti-atherosclerotic, and lipid-lowering activity. Only one report suggests that the methanol and aqueous extracts of this plant did not exert cytotoxic effects on normal mouse fibroblast cells. However, no clinical studies were reported.
Conclusions: Taken all together, X. moluccensis may be one of the best sources of pharmacologically active lead compounds. More research, however, is necessary to establish the safety and efficacy, and its toxicogenetic effects in animal models.
Competing Interests: Declaration of competing interest Authors declare no conflicts of interest.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: