Modulating the Selectivity and Stealth Properties of Ellipsoidal Polymersomes through a Multivalent Peptide Ligand Display.

Autor:	Tjandra KC; School of Chemistry, The University of New South Wales, Sydney, NSW, 2052, Australia.; Australian Centre for Nanomedicine, The University of New South Wales, Sydney, NSW, 2052, Australia.; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Australia., Forest CR; School of Chemistry, The University of New South Wales, Sydney, NSW, 2052, Australia.; Australian Centre for Nanomedicine, The University of New South Wales, Sydney, NSW, 2052, Australia.; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Australia., Wong CK; School of Chemistry, The University of New South Wales, Sydney, NSW, 2052, Australia.; Australian Centre for Nanomedicine, The University of New South Wales, Sydney, NSW, 2052, Australia.; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Australia., Alcantara S; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Australia.; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, 3000, Australia., Kelly HG; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Australia.; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, 3000, Australia., Ju Y; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Australia.; Department of Chemical Engineering, The University of Melbourne, Parkville, VIC, 3010, Australia., Stenzel MH; School of Chemistry, The University of New South Wales, Sydney, NSW, 2052, Australia.; School of Chemistry, Centre for Advanced Macromolecular Design (CAMD), The University of New South Wales, Sydney, NSW, 2052, Australia., McCarroll JA; Australian Centre for Nanomedicine, The University of New South Wales, Sydney, NSW, 2052, Australia.; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Australia.; Translational Cancer Nanomedicine Theme, Children's Cancer Institute, Lowy Cancer Research Centre, The University of New South Wales, Sydney, NSW, 2031, Australia.; School of Women's and Children's Health, Faculty of Medicine, The University of New South Wales, Sydney, NSW, 2052, Australia., Kavallaris M; Australian Centre for Nanomedicine, The University of New South Wales, Sydney, NSW, 2052, Australia.; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Australia.; Translational Cancer Nanomedicine Theme, Children's Cancer Institute, Lowy Cancer Research Centre, The University of New South Wales, Sydney, NSW, 2031, Australia.; School of Women's and Children's Health, Faculty of Medicine, The University of New South Wales, Sydney, NSW, 2052, Australia., Caruso F; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Australia.; Department of Chemical Engineering, The University of Melbourne, Parkville, VIC, 3010, Australia., Kent SJ; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Australia.; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, 3000, Australia., Thordarson P; School of Chemistry, The University of New South Wales, Sydney, NSW, 2052, Australia.; Australian Centre for Nanomedicine, The University of New South Wales, Sydney, NSW, 2052, Australia.; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Australia.
Jazyk:	angličtina
Zdroj:	Advanced healthcare materials [Adv Healthc Mater] 2020 Jul; Vol. 9 (13), pp. e2000261. Date of Electronic Publication: 2020 May 19.
DOI:	10.1002/adhm.202000261
Abstrakt:	There is a need for improved nanomaterials to simultaneously target cancer cells and avoid non-specific clearance by phagocytes. An ellipsoidal polymersome system is developed with a unique tunable size and shape property. These particles are functionalized with in-house phage-display cell-targeting peptide to target a medulloblastoma cell line in vitro. Particle association with medulloblastoma cells is modulated by tuning the peptide ligand density on the particles. These polymersomes has low levels of association with primary human blood phagocytes. The stealth properties of the polymersomes are further improved by including the peptide targeting moiety, an effect that is likely driven by the peptide protecting the particles from binding blood plasma proteins. Overall, this ellipsoidal polymersome system provides a promising platform to explore tumor cell targeting in vivo. (© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze:	MEDLINE
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