| Autor: |
Soundara Rajan T; Department of Biotechnology, School of Life Sciences, Karpagam Academy of Higher Education, Coimbatore 641021, India., Gugliandolo A; IRCCS Centro Neurolesi 'Bonino-Pulejo', Via Palermo, Contrada Casazza S.S.113, 98124 Messina, Italy., Bramanti P; IRCCS Centro Neurolesi 'Bonino-Pulejo', Via Palermo, Contrada Casazza S.S.113, 98124 Messina, Italy., Mazzon E; IRCCS Centro Neurolesi 'Bonino-Pulejo', Via Palermo, Contrada Casazza S.S.113, 98124 Messina, Italy. |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of molecular sciences [Int J Mol Sci] 2020 May 14; Vol. 21 (10). Date of Electronic Publication: 2020 May 14. |
| DOI: |
10.3390/ijms21103481 |
| Abstrakt: |
Tunneling nanotubes (TNTs) are thin membrane elongations among the cells that mediate the trafficking of subcellular organelles, biomolecules, and cues. Mesenchymal stem cells (MSCs) receive substantial attention in tissue engineering and regenerative medicine. Many MSCs-based clinical trials are ongoing for dreadful diseases including cancer and neurodegenerative diseases. Mitochondrial trafficking through TNTs is one of the mechanisms used by MSCs to repair tissue damage and to promote tissue regeneration. Preclinical studies linked with ischemia, oxidative stress, mitochondrial damage, inflammation, and respiratory illness have demonstrated the therapeutic efficacy of MSCs via TNTs-mediated transfer of mitochondria and other molecules into the injured cells. On the other hand, MSCs-based cancer studies showed that TNTs may modulate chemoresistance in tumor cells as a result of mitochondrial trafficking. In the present review, we discuss the role of TNTs from preclinical studies associated with MSCs treatment. We discuss the impact of TNTs formation between MSCs and cancer cells and emphasize to study the importance of TNTs-mediated MSCs protection in disease models. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
|
Nepřihlášeným uživatelům se plný text nezobrazuje |
K zobrazení výsledku je třeba se přihlásit.
|
