Activation of Leukopoiesis in Rat Blood with Trimecaine-Based Ionic Compounds.

Autor: Baktybayeva L; Biology and Biotechnology Department, Al-Farabi Kazakh National University, 050040 Almaty, Kazakhstan., Yu V; A. B. Bekturov Institute of Chemical Sciences, 050000 Almaty, Kazakhstan.; Center of Chemical Engineering, Kazakh-British Technical University, 050000 Almaty, Kazakhstan., Zazybin A; Center of Chemical Engineering, Kazakh-British Technical University, 050000 Almaty, Kazakhstan.; School of Chemical & Biochemical Engineering, Satbayev University, 050013 Almaty, Kazakhstan., Zolotareva D; School of Chemical & Biochemical Engineering, Satbayev University, 050013 Almaty, Kazakhstan., Dauletbakov A; Center of Chemical Engineering, Kazakh-British Technical University, 050000 Almaty, Kazakhstan.; School of Chemical & Biochemical Engineering, Satbayev University, 050013 Almaty, Kazakhstan.
Jazyk: angličtina
Zdroj: BioMed research international [Biomed Res Int] 2020 Jan 13; Vol. 2020, pp. 7636290. Date of Electronic Publication: 2020 Jan 13 (Print Publication: 2020).
DOI: 10.1155/2020/7636290
Abstrakt: A study of myelostimulating activity of ionic compounds-trimecaine alkyl iodide derivatives under the cipher BIV (BIV-117, BIV-118, and BIV-119) was conducted on a model of doxorubicin pancytopenia in white laboratory rats. It was established that the compounds BIV-117 and BIV-119 had a pronounced leukopoiesis-stimulating activity, exceeding the activity of the methyluracil as a comparison drug. Compounds BIV-117 and BIV-119 had erythropoiesis- and thrombocytopoiesis-stimulating activity at the level of methyluracil.
Competing Interests: All authors declare no conflicts of interest.
(Copyright © 2020 Lyailya Baktybayeva et al.)
Databáze: MEDLINE
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