Alcohol and multiple sclerosis: an immune system-based review.

Autor:	Fahim M; School of Medicine, Isfahan University of Medical Sciences Isfahan, Iran., Rafiee Zadeh A; School of Medicine, Isfahan University of Medical Sciences Isfahan, Iran., Shoureshi P; Department of Internal Medicine, Orange Park Medical Center Florida, USA., Ghadimi K; School of Medicine, Isfahan University of Medical Sciences Isfahan, Iran., Cheshmavar M; Department of Neurology, School of Medicine, Isfahan University of Medical Sciences Isfahan, Iran., Sheikhinia N; Department of Neurology, School of Medicine, Isfahan University of Medical Sciences Isfahan, Iran., Afzali M; Department of Neurology, School of Medicine, Isfahan University of Medical Sciences Isfahan, Iran.
Jazyk:	angličtina
Zdroj:	International journal of physiology, pathophysiology and pharmacology [Int J Physiol Pathophysiol Pharmacol] 2020 Apr 15; Vol. 12 (2), pp. 58-69. Date of Electronic Publication: 2020 Apr 15 (Print Publication: 2020).
Abstrakt:	Multiple sclerosis is a chronic inflammatory disease of the central nervous system (CNS). Although the exact etiology of multiple sclerosis is unknown, researchers suggest that genetic, environmental, and microbial factors play a central role in causing multiple sclerosis. Pathology of multiple sclerosis is based on inflammation as T cells enter the brain via disruptions in the blood-brain barrier, recognizing myelin as foreign antigen; and as a result, the T cells attack myelin and start the inflammatory processes, enhancing inflammatory cytokines and antibodies. Since previous studies show ethanol can suppress the immune system such as innate, humoral, and cellular immunity and increases the production of anti-inflammatory cytokines, we hypothesized maybe ethanol also have ameliorating effects on multiple sclerosis symptoms. Although alcohol induces apoptosis in oligodendrocytes and neurons, causing demyelination and affects CNS directly, in this study we will investigate ethanol's effects on some aspects of the immune system in multiple sclerosis. Competing Interests: None. (IJPPP Copyright © 2020.)
Databáze:	MEDLINE
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