| Autor: |
Kuronuma K; Kawaguchi Municipal Medical Center., Okumura Y; Division of Cardiology, Nihon University Itabashi Hospital., Morikawa T; Division of Cardiology, Nihon University Itabashi Hospital., Yokoyama K; Department of Cardiology, Nihon University Hospital., Matsumoto N; Department of Cardiology, Nihon University Hospital., Tachibana E; Kawaguchi Municipal Medical Center., Oiwa K; Yokohama Chuo Hospital., Matsumoto M; Yokohama Chuo Hospital., Kojima T; Sekishindo Hospital., Haruta H; Asaka Medical Center., Nomoto K; Tokyo Rinkai Hospital., Sonoda K; Tokyo Rinkai Hospital., Arima K; Kasukabe Medical Center., Kogawa R; Kasukabe Medical Center., Takahashi F; Yasuda Hospital., Kotani T; Makita General Hospital., Ohkubo K; Itabashi Medical Association Hospital., Fukushima S; Ukima Central Hospital., Itou S; Itou Cardiovascular Clinic., Kondo K; Kondo Clinic., Chiku M; Keiai Clinic., Ohno Y; Ohno Medical Clinic., Onikura M; Onikura Clinic., Hirayama A; Division of Cardiology, Nihon University Itabashi Hospital. |
| Jazyk: |
angličtina |
| Zdroj: |
International heart journal [Int Heart J] 2020 May 30; Vol. 61 (3), pp. 492-502. Date of Electronic Publication: 2020 May 15. |
| DOI: |
10.1536/ihj.19-560 |
| Abstrakt: |
Atrial fibrillation (AF) and heart failure (HF) often coexist. The aims of this study were to explore the factors associated with the serum levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), and the association between prognosis and a history of HF or the serum NT-proBNP level in Japanese patients with AF.The present sub-study was based on the SAKURA AF Registry, a Japanese multicenter observational registry that included 3267 AF patients (median follow-up period: 39 months). All the patients were receiving warfarin or any of four direct oral anticoagulants. Serum NT-proBNP levels were available for 2417 patients, and the median value was 508 (interquartile range 202-1095) pg/mL at the time of enrollment. Log NT-proBNP was associated with non-paroxysmal AF, creatinine clearance > 60 mL/minute, history of HF and ischemic heart disease, antiarrhythmic drug use, anemia, being elderly female, and history of AF ablation. The relative risk of adverse clinical events, except major bleeding, was significantly higher in the highest NT-proBNP quartile as compared to the lowest quartile (adjusted hazard ratios: 2.87 for death, 2.39 for stroke), but a history of HF was associated only with a higher incidence of all-cause death.Concomitant HF was associated with a higher mortality, but the high NT-proBNP was associated with higher mortality and stroke events. In Japanese AF patients receiving anticoagulant treatment, high serum NT-proBNP levels predict the risk for both stroke events and deaths, and intensive follow-up is needed in such patients. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
