Herpesviruses oral shedding and viremia in renal transplant recipients: A longitudinal study.

Autor: Sarmento DJS; Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil., Tozetto-Mendoza TR; Laboratory of Virology, School of Medicine, Institute of Tropical Medicine of São Paulo, University of São Paulo, São Paulo, Brazil., de Souza ACMF; Laboratory of Virology, School of Medicine, Institute of Tropical Medicine of São Paulo, University of São Paulo, São Paulo, Brazil., Maciel R; Division of Renal Transplantation, Social Institute of Healthcare, Campina Grande, Brazil., Paiao H; Laboratory of Virology, School of Medicine, Institute of Tropical Medicine of São Paulo, University of São Paulo, São Paulo, Brazil., Lima SH; Laboratory of Virology, School of Medicine, Institute of Tropical Medicine of São Paulo, University of São Paulo, São Paulo, Brazil., Cristelli M; Division of Renal Transplantation, Kidney and Hypertension Hospital, Federal University of São Paulo, São Paulo, Brazil., Pestana JOMA; Division of Renal Transplantation, Kidney and Hypertension Hospital, Federal University of São Paulo, São Paulo, Brazil., Braz-Silva PH; Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.; Laboratory of Virology, School of Medicine, Institute of Tropical Medicine of São Paulo, University of São Paulo, São Paulo, Brazil., Gallottini M; Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Transplant infectious disease : an official journal of the Transplantation Society [Transpl Infect Dis] 2020 Aug; Vol. 22 (4), pp. e13330. Date of Electronic Publication: 2020 Jun 03.
DOI: 10.1111/tid.13330
Abstrakt: Background: The objective was to assess the oral shedding and viremia of human herpesviruses in renal transplant recipients.
Methods: This is a cohort study in which the participants were examined in three different periods: the first within 24 hours before renal transplantation and the second and third ones 15-20 and 45-60 days after the transplantation. Mouthwash and blood samples were collected in each period and then submitted to screening for the presence of eight types of human herpesviruses by using multiplex PCR.
Results: HSV-1 and EBV were more frequent in the saliva after renal transplantation, 15- to 20-day period after the transplant. EBV was found in the saliva of 26 (35.6%) patients before renal transplantation and in 56.2% and 46.6% of them, in the 15- to 20-day and 45- to 60-day periods after the transplant, respectively. High detection rates (75.3%-78.1%) were found for HHV-7 despite the lack of significant variations between the study periods. There was no concordance between herpesviruses oral shedding and viremia.
Conclusion: We concluded that the pattern of excretion of HSV-1 and EBV in saliva is changed immediately after renal transplantation, increasing in the 15- to 20-day period after the transplant surgery. No concordance between herpesviruses oral shedding and viremia was observed.
(© 2020 Wiley Periodicals LLC.)
Databáze: MEDLINE
Externí odkaz: