Relevance of KDPI value and acute rejection on kidney transplant outcomes in recipients with delayed graft function - a retrospective study.

Autor: Arias-Cabrales CE; Nephrology, Hospital del Mar, Barcelona, Spain., Pérez-Sáez MJ; Nephrology, Hospital del Mar, Barcelona, Spain., Redondo-Pachón D; Nephrology, Hospital del Mar, Barcelona, Spain., Buxeda A; Nephrology, Hospital del Mar, Barcelona, Spain., Burballa C; Nephrology, Hospital del Mar, Barcelona, Spain., Duran X; Methodological and Biostatistics consultancy, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain., Mir M; Nephrology, Hospital del Mar, Barcelona, Spain., Crespo M; Nephrology, Hospital del Mar, Barcelona, Spain., Pascual J; Nephrology, Hospital del Mar, Barcelona, Spain.
Jazyk: angličtina
Zdroj: Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 2020 Sep; Vol. 33 (9), pp. 1071-1077. Date of Electronic Publication: 2020 Jun 15.
DOI: 10.1111/tri.13654
Abstrakt: Delayed graft function (DGF) is associated with poorer graft survival and higher rate of acute rejection (AR). It is unknown whether this negative influence relies on the increased risk of AR or the DGF itself. The different Kidney Donor Profile Index (KDPI) values may also play a role in this interaction. Retrospective study aimed to evaluate the impact of DGF on graft function and graft survival in a subset of KT recipients (2004-2017). We also analyzed the relationship between KDPI and DGF. The study includes 601 KT, 226 of them (37%) developed DGF. Graft survival was lower in patients with DGF compared with non-DGF patients. Multivariable analysis revealed DGF as risk factor for graft loss, independently of the presence or not of acute rejection. Between DGF patients, we observed poorer graft survival in patients with higher KDPI value (>85%). We observed a trend of a greater impact of KDPI in patients with DGF, although this interaction was not statistically significant. Additionally, we observed poorer 12-month graft function in DGF patients. DGF is related to poorer graft survival independently of the developed acute rejection. This negative impact might be influenced by high KDPI values.
(© 2020 Steunstichting ESOT. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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