Hippocampal Subfield Volumes in Middle-Aged Adults at Risk of Dementia.

Autor:	McKeever A; Department of Psychiatry, University of Cambridge, UK., Paris AF; Department of Psychiatry, University of Cambridge, UK., Cullen J; Department of Psychiatry, University of Cambridge, UK., Hayes L; Department of Psychiatry, University of Cambridge, UK., Ritchie CW; Centre for Dementia Prevention, University of Edinburgh, UK., Ritchie K; Centre for Dementia Prevention, University of Edinburgh, UK.; Inserm, University Montpellier, France., Waldman AD; Centre for Dementia Prevention, University of Edinburgh, UK., Wells K; The Centre for Psychiatry, Imperial College London, UK., Busza A; Clinical Imaging Facility, Imperial College London, UK., Carriere I; Inserm, University Montpellier, France., O'Brien JT; Department of Psychiatry, University of Cambridge, UK., Su L; Department of Psychiatry, University of Cambridge, UK.
Jazyk:	angličtina
Zdroj:	Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2020; Vol. 75 (4), pp. 1211-1218.
DOI:	10.3233/JAD-200238
Abstrakt:	Background: Alzheimer's disease (AD) begins decades before the onset of dementia. There is a need to investigate biomarkers of early AD for use in clinical trials and to facilitate early intervention. Objective: We aimed to determine whether changes in hippocampal subfield volumes in healthy middle-aged adults were associated with risk of future dementia. Methods: We included 150 participants from the PREVENT-Dementia cohort, which recruited subjects aged 40-59 with or without a family history of dementia (FHD; included here were 81 with FHD and 69 without). Hippocampal subfield volumes were segmented from high resolution T2-weighted 3T MRI images taken at baseline and 2-year follow-up. Results: FHD and greater 20 year-risk of dementia due to cardiovascular risk factors were both associated with lower CA1 volume. FHD was also associated with a relative increase in combined CA3, CA4, and dentate gyrus volume between baseline and follow-up. Conclusion: CA1 atrophy may commence as early as middle-age in those with a high risk of future dementia, while increases in CA3, CA4, and dentate gyrus volume may be a response to early AD in the form of inflammation or neurogenesis.
Databáze:	MEDLINE
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