Amygdalar nuclei and hippocampal subfields on MRI: Test-retest reliability of automated volumetry across different MRI sites and vendors.

Autor: Quattrini G; Laboratory of Alzheimer's Neuroimaging and Epidemiology (LANE), IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy. Electronic address: gquattrini@fatebenefratelli.eu., Pievani M; Laboratory of Alzheimer's Neuroimaging and Epidemiology (LANE), IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Jovicich J; Center for Mind Brain Sciences, University of Trento, Trento, Italy., Aiello M; IRCCS SDN, Napoli, Italy., Bargalló N; Department of Neuroradiology and Image Research Platform, Hospital Clínic de Barcelona, IDIBAPS, Barcelona, Spain., Barkhof F; Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing, University College London, UK., Bartres-Faz D; Department of Medicine and Health Sciences, Faculty of Medicine, Universitat de Barcelona and IDIBAPS, Barcelona, Spain., Beltramello A; Department of Radiology, IRCCS 'Sacro Cuore-Don Calabria', Negrar, Verona, Italy., Pizzini FB; Radiology, Department of Diagnostic and Public Health, University of Verona, Verona, Italy., Blin O; Aix-Marseille University, UMR-INSERM 1106, Service de Pharmacologie Clinique, APHM, Marseille, France., Bordet R; Aix-Marseille Université, INSERM U 1106, 13005, Marseille, France., Caulo M; University 'G. d'Annunzio' of Chieti, Chieti, Italy., Constantinides M; Interbalkan Medical Centre of Thessaloniki, Thessaloniki, Greece., Didic M; Aix-Marseille Université, Inserm, Institut de Neurosciences des Systèmes (INS) UMR_S 1106, 13005, Marseille, France; APHM, Timone, Service de Neurologie et Neuropsychologie, Hôpital Timone Adultes, Marseille, France., Drevelegas A; Interbalkan Medical Centre of Thessaloniki, Thessaloniki, Greece., Ferretti A; University 'G. d'Annunzio' of Chieti, Chieti, Italy., Fiedler U; Institutes and Clinics of the University Duisburg-Essen, Essen, Germany., Floridi P; Perugia General Hospital, Neuroradiology Unit, Perugia, Italy., Gros-Dagnac H; ToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, France., Hensch T; Department of Psychiatry and Psychotherapy, University of Leipzig Medical Center, Leipzig, Germany., Hoffmann KT; Department of Neuroradiology, University Hospital Leipzig, Leipzig, Germany., Kuijer JP; Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands., Lopes R; INSERM U1171, Neuroradiology Department, University Hospital, Lille, France., Marra C; Catholic University, Fondazione Policlinico A. Gemelli, IRCCS, Rome, Italy., Müller BW; LVR-Hospital Essen, Department for Psychiatry and Psychotherapy, Faculty of Medicine, University of Duisburg-Essen, Germany., Nobili F; Department of Neuroscience (DINOGMI), University of Genoa, Genoa, Italy; IRCCS, Ospedale Policlinico San Martino, Genova, Italy., Parnetti L; Section of Neurology, Department of Medicine, University of Perugia, Perugia, Italy., Payoux P; ToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, France., Picco A; Department of Neuroscience (DINOGMI), University of Genoa, Genoa, Italy., Ranjeva JP; CRMBM-CEMEREM, UMR 7339, Aix-Marseille University, CNRS, Marseille, France., Roccatagliata L; IRCCS, Ospedale Policlinico San Martino, Genova, Italy; Department of Health Science (DISSAL), University of Genoa, Genoa, Italy., Rossini PM; Dept. Neuroscience & Rehabilitation, IRCCS San Raffaele-Pisana, Rome, Italy., Salvatore M; IRCCS SDN, Napoli, Italy., Schonknecht P; Department of Psychiatry and Psychotherapy, University of Leipzig Medical Center, Leipzig, Germany., Schott BH; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen (UMG), Göttingen, Germany; Leibniz Institute for Neurobiology, Magdeburg, Germany; German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany., Sein J; CRMBM-CEMEREM, UMR 7339, Aix-Marseille University, CNRS, Marseille, France., Soricelli A; IRCCS SDN, Napoli, Italy., Tarducci R; Perugia General Hospital, Medical Physics Unit, Perugia, Italy., Tsolaki M; Aristotle University of Thessaloniki, Thessaloniki, Greece., Visser PJ; Department of Neurology, Alzheimer Centre, VU Medical Centre, Amsterdam, Netherlands; Maastricht University, Maastricht, Netherlands., Wiltfang J; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen (UMG), Göttingen, Germany; Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal; German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany., Richardson JC; Neurosciences Therapeutic Area, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, United Kingdom., Frisoni GB; Laboratory of Alzheimer's Neuroimaging and Epidemiology (LANE), IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; Memory Clinic and LANVIE-Laboratory of Neuroimaging of Aging, Hospitals and University of Geneva, Geneva, Switzerland., Marizzoni M; Laboratory of Alzheimer's Neuroimaging and Epidemiology (LANE), IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Jazyk: angličtina
Zdroj: NeuroImage [Neuroimage] 2020 Sep; Vol. 218, pp. 116932. Date of Electronic Publication: 2020 May 13.
DOI: 10.1016/j.neuroimage.2020.116932
Abstrakt: Background: The amygdala and the hippocampus are two limbic structures that play a critical role in cognition and behavior, however their manual segmentation and that of their smaller nuclei/subfields in multicenter datasets is time consuming and difficult due to the low contrast of standard MRI. Here, we assessed the reliability of the automated segmentation of amygdalar nuclei and hippocampal subfields across sites and vendors using FreeSurfer in two independent cohorts of older and younger healthy adults.
Methods: Sixty-five healthy older (cohort 1) and 68 younger subjects (cohort 2), from the PharmaCog and CoRR consortia, underwent repeated 3D-T1 MRI (interval 1-90 days). Segmentation was performed using FreeSurfer v6.0. Reliability was assessed using volume reproducibility error (ε) and spatial overlapping coefficient (DICE) between test and retest session.
Results: Significant MRI site and vendor effects (p ​< ​.05) were found in a few subfields/nuclei for the ε, while extensive effects were found for the DICE score of most subfields/nuclei. Reliability was strongly influenced by volume, as ε correlated negatively and DICE correlated positively with volume size of structures (absolute value of Spearman's r correlations >0.43, p ​< ​1.39E-36). In particular, volumes larger than 200 ​mm 3 (for amygdalar nuclei) and 300 ​mm 3 (for hippocampal subfields, except for molecular layer) had the best test-retest reproducibility (ε ​< ​5% and DICE ​> ​0.80).
Conclusion: Our results support the use of volumetric measures of larger amygdalar nuclei and hippocampal subfields in multisite MRI studies. These measures could be useful for disease tracking and assessment of efficacy in drug trials.
Competing Interests: Declaration of competing interest None.
(Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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