Estimates of beta cell function adjusted by anthropometric markers in patients with T2DM.

Autor: Zhang M; Department of Endocrinology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.; Postdoctoral Research Station of Public Health, School of Public Health, Xinjiang Medical University, Urumqi, China., Su Y; Health Management Institute, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China., Quan L; Department of Endocrinology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China., Jiang S; Department of Endocrinology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China., Yao H; Postdoctoral Research Station of Public Health, School of Public Health, Xinjiang Medical University, Urumqi, China.; The Key Laboratory of Xinjiang Metabolic Disease, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Jazyk: angličtina
Zdroj: Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2020 Sep; Vol. 47 (9), pp. 1509-1516. Date of Electronic Publication: 2020 Jun 04.
DOI: 10.1111/1440-1681.13337
Abstrakt: We sought to determine whether adjusting the indices used to assess beta cell function by anthropometric markers of obesity improves their clinical value in a diabetic population. We conducted a cross-sectional survey of 3732 diabetic patients who underwent a 100 g carbohydrate meal test. Insulin secretion was estimated using HOMA-B of steady state as well as △C 0-30 /△G 0-30 , △AUC c30-120 /△AUC G30-120 and CPI n for dynamic state. Body weight index, waist circumference, waist-hip ratio and body surface area were recorded. The final analysis included 2873 T2DM patients. Correlation analyses showed that there was a poor correlation between diabetic duration and CPI 30 (r = -.040, P < .05), and there were no remarkable changes in the correlation coefficient after CPI 30 was divided by BMI, WC, WHR, or body surface area, respectively. The same was found for the correlation between HbA1c and CPI 120 with these measures. The main determinants of diabetic duration were age (β = 0.388, P < .001), log HOMA-IR (β = -0.328, P < .001), CPI 30 (β = -0.045, P = .011). There were no remarkable changes in β weights between diabetic duration and CPI 30 when it was corrected with anthropometric markers in the multiple stepwise linear regression analyses. The same was found between HbA 1c and CPI 120 . CPI 30 and CPI 120 are more practical indexes. Correcting the indices used to estimate the beta cell function by anthropometric markers of obesity may not improve their correlations with diabetic duration or HbA 1c in a diabetic population.
(© 2020 John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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