| Autor: |
Kiourtzidis M; Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Von-Danckelmann-Platz 2, 06120 Halle (Saale), Germany., Kühn J; Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Von-Danckelmann-Platz 2, 06120 Halle (Saale), Germany., Brandsch C; Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Von-Danckelmann-Platz 2, 06120 Halle (Saale), Germany., Baur AC; Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Von-Danckelmann-Platz 2, 06120 Halle (Saale), Germany.; Competence Cluster of Cardiovascular Health and Nutrition (nutriCARD), Halle-Jena-Leipzig, Germany., Wensch-Dorendorf M; Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Von-Danckelmann-Platz 2, 06120 Halle (Saale), Germany., Stangl GI; Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Von-Danckelmann-Platz 2, 06120 Halle (Saale), Germany.; Competence Cluster of Cardiovascular Health and Nutrition (nutriCARD), Halle-Jena-Leipzig, Germany. |
| Abstrakt: |
Circulating 25-hydroxyvitamin D (25(OH)D) is regarded as the most reliable biomarker of vitamin D status. However, limited data exist concerning the suitability of 25(OH)D as an indicator of body vitamin D stores and the ability of adipose tissue to mobilize vitamin D. In the first study, in which male mice received different vitamin D 3 doses for three weeks, we found strong linear response relationships between vitamin D 3 intake and levels of vitamin D 3 in the plasma ( p < 0.001), liver ( p < 0.001) and adipose tissues ( p < 0.001), and strong positive correlations between plasma and tissue stores of vitamin D 3 ( p < 0.001). Plasma levels of 25(OH)D 3 and 24,25-dihydroxyvitamin D 3 (24,25(OH) 2 D 3 ) showed weak or no correlations with tissue vitamin D 3 stores. Data from a second study demonstrate a strong and rapid response of plasma 25(OH)D 3 in vitamin D 3 -treated mice with a low vitamin D status. Additionally, mice fed a vitamin D-free diet showed a strong and rapid decline in vitamin D 3 in the liver, whereas the decline in different adipose tissues was distinctly lower than that in the liver. To conclude, tissue stores of vitamin D 3 were best reflected by plasma vitamin D 3 . In contrast to the liver, adipose tissues responded less sensitively to an absence of vitamin D intake. |
