Self-Generated Whisker Movements Drive State-Dependent Sensory Input to Developing Barrel Cortex.

Autor:	Dooley JC; Department of Psychological & Brain Sciences, University of Iowa, Iowa City, IA 52242, USA; DeLTA Center, University of Iowa, Iowa City, IA 52242 USA. Electronic address: james-c-dooley@uiowa.edu., Glanz RM; Department of Psychological & Brain Sciences, University of Iowa, Iowa City, IA 52242, USA., Sokoloff G; Department of Psychological & Brain Sciences, University of Iowa, Iowa City, IA 52242, USA; DeLTA Center, University of Iowa, Iowa City, IA 52242 USA; Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242 USA., Blumberg MS; Department of Psychological & Brain Sciences, University of Iowa, Iowa City, IA 52242, USA; Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA 52242, USA; DeLTA Center, University of Iowa, Iowa City, IA 52242 USA; Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242 USA. Electronic address: mark-blumberg@uiowa.edu.
Jazyk:	angličtina
Zdroj:	Current biology : CB [Curr Biol] 2020 Jun 22; Vol. 30 (12), pp. 2404-2410.e4. Date of Electronic Publication: 2020 May 14.
DOI:	10.1016/j.cub.2020.04.045
Abstrakt:	Cortical development is an activity-dependent process [1-3]. Regarding the role of activity in the developing somatosensory cortex, one persistent debate concerns the importance of sensory feedback from self-generated movements. Specifically, recent studies claim that cortical activity is generated intrinsically, independent of movement [3, 4]. However, other studies claim that behavioral state moderates the relationship between movement and cortical activity [5-7]. Thus, perhaps inattention to behavioral state leads to failures to detect movement-driven activity [8]. Here, we resolve this issue by associating local field activity (i.e., spindle bursts) and unit activity in the barrel cortex of 5-day-old rats with whisker movements during wake and myoclonic twitches of the whiskers during active (REM) sleep. Barrel activity increased significantly within 500 ms of whisker movements, especially after twitches. Also, higher-amplitude movements were more likely to trigger barrel activity; when we controlled for movement amplitude, barrel activity was again greater after a twitch than a wake movement. We then inverted the analysis to assess the likelihood that increases in barrel activity were preceded within 500 ms by whisker movements: at least 55% of barrel activity was attributable to sensory feedback from whisker movements. Finally, when periods with and without movement were compared, 70%-75% of barrel activity was movement related. These results confirm the importance of sensory feedback from movements in driving activity in sensorimotor cortex and underscore the necessity of monitoring sleep-wake states to ensure accurate assessments of the contributions of the sensory periphery to activity in developing somatosensory cortex. Competing Interests: Declaration of Interests The authors declare no competing interests. (Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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