Comparison of Centella with Flavonoids for Treatment of Symptoms in Hemorrhoidal Disease and After Surgical Intervention: A Randomized Clinical Trial.

Autor: Chiaretti M; Department of General Surgery and Specialties 'Paride Stefanini', Sapienza University of Rome, Rome, 00161, Italy. massimo.chiaretti@uniroma1.it., Fegatelli DA; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, 00161, Italy., Pappalardo G; Department of General Surgery and Specialties 'Paride Stefanini', Sapienza University of Rome, Rome, 00161, Italy., Venti MDS; Department of Molecular Medicine, Sapienza University of Rome, Rome, 00161, Italy., Chiaretti AI; Department of General Surgery and Specialties 'Paride Stefanini', Sapienza University of Rome, Rome, 00161, Italy.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2020 May 14; Vol. 10 (1), pp. 8009. Date of Electronic Publication: 2020 May 14.
DOI: 10.1038/s41598-020-64772-0
Abstrakt: Phlebotonics' effects were evaluated to reduce time-to-stop bleeding and anal irritation in 130 patients who complained of hemorrhoidal disease (HD); bleeding and pain after hemorrhoidectomy (31 patients) and hemorrhoidal thrombosis (34 patients) in the short time. Sixty patients were randomized to receive the routine treatment (both conservative and surgical) (control Group C). The treated group (both conservative and surgical) was divided into two subgroups: one treated with flavonoids (Group A, n = 73), the other with Centella (Group B, n = 66). Time-to-stop bleeding was checked at baseline and checkups (0 up to day 42). Healing was estimated with Kaplan-Meier method, the Kruskal-Wallis test estimated changes in the VAS scores. The HD median time-to-stop bleeding was 2 weeks for Groups A and B; 3 weeks for Group C. VAS scores comparison among Groups (irritation): A vs C, p = 0.007; B vs C, p = 0.041; and A vs B, p = 0.782 resulted respectively. As for operated hemorrhoids, the time-to-stop bleeding was 3 and 4 weeks in Groups A and B and 5 in Group C. Histopathology showed an association between flavonoids and piles' fibrosis (p = 0.008). Phlebotonics in HD, as well as after surgery, showed significant beneficial effects. Flavonoids are the most effective phlebotonics against bleeding and anal irritation.
Databáze: MEDLINE
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