Coagulopathy in COVID-19: Manifestations and management.

Autor:	Mucha SR; Critical Care Medicine, Respiratory Institute, Cleveland Clinic.; Clinical Instructor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH., Dugar S; Pulmonary Medicine, Cleveland Clinic.; Clinical Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH., McCrae K; Hematology and Medical Oncology, and Cellular and Molecular Medicine, Cleveland Clinic.; Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH., Joseph D; Cardiovascular Medicine, Cleveland Clinic.; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH., Bartholomew J; Cardiovascular Medicine, Cleveland Clinic barthoj@ccf.org.; Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH barthoj@ccf.org., Sacha GL; Inpatient Pharmacy, Cleveland Clinic., Militello M; Inpatient Pharmacy, Cleveland Clinic.
Jazyk:	angličtina
Zdroj:	Cleveland Clinic journal of medicine [Cleve Clin J Med] 2020 Jul 31; Vol. 87 (8), pp. 461-468. Date of Electronic Publication: 2020 Jul 31.
DOI:	10.3949/ccjm.87a.ccc024
Abstrakt:	Severe COVID-19 illness is associated with intense inflammation, leading to high rates of thrombotic complications that increase morbidity and mortality. Markedly elevated levels of D-dimer with normal fibrinogen levels are the hallmark laboratory findings of severe COVID-19- associated coagulopathy. Prophylaxis against venous thromboembolism is paramount for all hospitalized patients, with more aggressive prophylaxis and screening recommended for patients with D-dimer levels above 3.0 μg/mL. Point-of-care ultrasonography is the imaging method of choice for patients at high risk, as it entails minimal risk of exposing providers to the virus. (Copyright © 2020 The Cleveland Clinic Foundation. All Rights Reserved.)
Databáze:	MEDLINE
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