Cryptococcal meningitis in a patient with multiple sclerosis on dimethyl fumarate treatment: A case report.

Autor: Workel HH; Department of Neurology, Isala Hospital, Zwolle, the Netherlands. Electronic address: h.h.workel@isala.nl., Wolfhagen MJHM; Laboratory of Medical Microbiology and Infectious Diseases, Isala Hospital, Zwolle, the Netherlands., Bouwhuis JW; Department of Internal Medicine, Isala Hospital, Zwolle, the Netherlands., Kloosterziel ME; Department of Neurology, Isala Hospital, Zwolle, the Netherlands.
Jazyk: angličtina
Zdroj: Multiple sclerosis and related disorders [Mult Scler Relat Disord] 2020 Jul; Vol. 42, pp. 102137. Date of Electronic Publication: 2020 Apr 29.
DOI: 10.1016/j.msard.2020.102137
Abstrakt: Introduction: We present a case of meningitis caused by Cryptococcus neoformans var. grubii in a 46-year old non-HIV-infected patient with multiple sclerosis, treated with dimethyl fumarate monotherapy. We identified no other risk factors for developing cryptococcal meningitis. The patient presented with a slowly progressive headache during preceding weeks and acute onset of confusion, nausea and vomiting. Clinical examination revealed intermittent disorientation without focal neurological symptoms. A lumbar puncture showed an opening pressure of > 50cmH 2 O. Diagnosis of cryptococcal meningitis was made after culture of Cryptococcus neoformans var. grubii of cerebrospinal fluid.
Conclusion: This case emphasizes clinicians should bear in mind the possibility of cryptococcal meningitis in patients treated with dimethyl fumarate.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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