MicroRNA-22-3p alleviates spinal cord ischemia/reperfusion injury by modulating M2 macrophage polarization via IRF5.
Autor: | Fang H; Department of Anesthesiology, Guizhou Provincial People's Hospital, Guiyang, P.R. China.; Department of Anesthesiology, Guizhou University People's Hospital, Guiyang, P.R. China.; Laboratory of Anesthesiology and Perioperative Medicine, Guizhou University School of Medicine, Guiyang, P.R. China., Yang M; Department of Anesthesiology, Guizhou Provincial People's Hospital, Guiyang, P.R. China.; Department of Anesthesiology, Guizhou University People's Hospital, Guiyang, P.R. China.; Laboratory of Anesthesiology and Perioperative Medicine, Guizhou University School of Medicine, Guiyang, P.R. China., Pan Q; Department of Anesthesiology, Guizhou Provincial People's Hospital, Guiyang, P.R. China.; Department of Anesthesiology, Guizhou University People's Hospital, Guiyang, P.R. China.; Laboratory of Anesthesiology and Perioperative Medicine, Guizhou University School of Medicine, Guiyang, P.R. China., Jin HL; Department of Anesthesiology, Guizhou Provincial People's Hospital, Guiyang, P.R. China.; Department of Anesthesiology, Guizhou University People's Hospital, Guiyang, P.R. China.; Laboratory of Anesthesiology and Perioperative Medicine, Guizhou University School of Medicine, Guiyang, P.R. China., Li HF; Department of Anesthesiology, West China Second University Hospital, Sichuan University, Chengdu, P.R. China., Wang RR; Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, P.R. China., Wang QY; Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, P.R. China., Zhang JP; Department of Anesthesiology, Guizhou Provincial People's Hospital, Guiyang, P.R. China.; Department of Anesthesiology, Guizhou University People's Hospital, Guiyang, P.R. China.; Laboratory of Anesthesiology and Perioperative Medicine, Guizhou University School of Medicine, Guiyang, P.R. China. |
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Jazyk: | angličtina |
Zdroj: | Journal of neurochemistry [J Neurochem] 2021 Jan; Vol. 156 (1), pp. 106-120. Date of Electronic Publication: 2020 Jun 08. |
DOI: | 10.1111/jnc.15042 |
Abstrakt: | Cell death after spinal cord ischemia/reperfusion (I/R) can occur through necrosis, apoptosis, and autophagy, resulting in changes to the immune environment. However, the molecular mechanism of this immune regulation is not clear. Accumulating evidence indicates that microRNAs (miRs) play a crucial role in the pathogenesis of spinal cord I/R injury. Here, we hypothesized miR-22-3p may be involved in spinal cord I/R injury by interacting with interferon regulatory factor (IRF) 5. Rat models of spinal cord I/R injury were established by 12-min occlusion of the aortic arch followed by 48-hr reperfusion, with L (© 2020 International Society for Neurochemistry.) |
Databáze: | MEDLINE |
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