| Autor: |
Hagemann RA; Department of Cardiology, Faculty of Health Sciences, Gentofte Hospital, University of Copenhagen, Herlev & Kildegårdsvej 28, 2900, Hellerup, Denmark. rikke@dvc.dk.; Cardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Kildegårdsvej 28, 2900, Hellerup, Denmark. rikke@dvc.dk., Hoffmann S; Department of Anaesthesiology and Intensive Care Medicine, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400, Copenhagen, Denmark., Brainin P; Department of Cardiology, Faculty of Health Sciences, Gentofte Hospital, University of Copenhagen, Herlev & Kildegårdsvej 28, 2900, Hellerup, Denmark., Hagemann CA; Department of Cardiology, Faculty of Health Sciences, Gentofte Hospital, University of Copenhagen, Herlev & Kildegårdsvej 28, 2900, Hellerup, Denmark., Fritz-Hansen T; Department of Cardiology, Faculty of Health Sciences, Gentofte Hospital, University of Copenhagen, Herlev & Kildegårdsvej 28, 2900, Hellerup, Denmark., Olsen FJ; Department of Cardiology, Faculty of Health Sciences, Gentofte Hospital, University of Copenhagen, Herlev & Kildegårdsvej 28, 2900, Hellerup, Denmark., Møgelvang R; Department of Cardiology, Faculty of Health Sciences, Gentofte Hospital, University of Copenhagen, Herlev & Kildegårdsvej 28, 2900, Hellerup, Denmark., Biering-Sørensen T; Department of Cardiology, Faculty of Health Sciences, Gentofte Hospital, University of Copenhagen, Herlev & Kildegårdsvej 28, 2900, Hellerup, Denmark.; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. |
| Abstrakt: |
This study aimed to clarify the diagnostic and prognostic potential of strain rate in patients with suspected stable angina pectoris (SAP). Strain rate by 2-dimensional speckle tracking echocardiography (2DSTE) has been suggested to be able to diagnose coronary artery disease (CAD) and predict cardiovascular events in various patient groups. Prospectively enrolled patients (n = 296) with suspected SAP, no previous cardiac disease, and normal left ventricular ejection fraction were examined by 2DSTE, exercise ECG, and coronary angiography. Obstructive CAD was defined as stenosis ≥ 70% in ≥ 1 coronary artery on coronary angiography (n = 107). Major adverse cardiac events (MACE) included myocardial infarction, heart failure, atrial fibrillation, and stroke. In multivariable analysis adjusted for baseline data, conventional echocardiography, and Duke score, early diastolic strain rate (SRe) was independently associated with significant CAD with a 1.35 increased risk of having CAD per 0.1 decrease in SRe (OR = 1.35, 95% CI 1.03-1.76, P = 0.027). Peak velocity of early diastolic filling (E)/SRe was not associated with significant CAD (OR = 1.14, 95% CI 0.81-1.62, P = 0.445). MACE occurred in 34 patients (12%) during follow-up (median 3.5 years) and both SRe (HR 1.26, 95% CI (1.07-1.49), P = 0.006) and E/SRe (HR 1.24, 95% CI (1.04-1.47), P = 0.017) were independent predictors after multivariable adjustment. In patients with suspected SAP, SRe by 2DSTE was independently associated with presence of CAD. In addition, SRe and E/SRe provided independent and incremental prognostic value for predicting future MACE. |
Full text from SpringerLink