Docking analysis of importin-11 homology model with the phyto compounds towards colorectal cancer treatment.
| Autor: | Selvaraj J; Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India., Ponnulakshmi R; Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai-600 078, India., Abilasha S; Department of Anatomy, Asan Memorial Dental College & Hospital, Asan Nagar, Chengalpattu, Tamil Nadu., Nalini D; Central Research Laboratory, Meenakshi Ammal Dental College and Hospital, Chennai, Tamil Nadu, India., Vijayalakshmi P; DBT-BIF Centre, PG & Research Department of Biotechnology & Bioinformatics, Holy Cross College (Autonomous), Trichy, Tamilnadu., Vishnupriya V; Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India., Mohan SK; Department of Biochemistry, Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai-600 123, Tamil Nadu, India. |
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| Jazyk: | angličtina |
| Zdroj: | Bioinformation [Bioinformation] 2020 Feb 29; Vol. 16 (2), pp. 153-159. Date of Electronic Publication: 2020 Feb 29 (Print Publication: 2020). |
| DOI: | 10.6026/97320630016153 |
| Abstrakt: | Colorectal cancer (CRC) is the most familiar malignancy worldwide. Hence, searching for novel therapeutic options is of highest priority. Therefore, it is of interest to design inhibitors to the protein target importin-11, which transports β-catenin linked to colon cancer cells. However, the structure of importin-11 is not known. Hence, we use a homology model of importin-11 to dock potential interactions with five phyto compounds using molecular interaction features for further consideration. (© 2020 Biomedical Informatics.) |
| Databáze: | MEDLINE |
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