Diffuse large B-cell lymphoma relapse presenting as extensive neurolymphomatosis.
| Autor: | Nepal P; Department of Radiology and Medical Imaging, St. Vincent's Medical Center, Bridgeport, CT, USA., Batchala PP; Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, VA, USA., Rehm PK; Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, VA, USA., Fadul CE; Division of Neuro-oncology, Department of Neurology, University of Virginia Health System, Charlottesville, VA, USA. |
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| Jazyk: | angličtina |
| Zdroj: | The neuroradiology journal [Neuroradiol J] 2020 Jun; Vol. 33 (3), pp. 230-235. Date of Electronic Publication: 2020 May 13. |
| DOI: | 10.1177/1971400920924799 |
| Abstrakt: | A 56-year-old woman with a history of diffuse large B-cell non-Hodgkin lymphoma (DLBCL-NHL) in remission for two years presented with weight loss and multifocal sensory/motor symptoms. Magnetic resonance imaging (MRI) of the neuraxis and whole-body FDG PET/CT led to a diagnosis of secondary neurolymphomatosis (NL). MRI demonstrated extensive thickening and enhancement of multiple cranial nerves and peripheral nerve plexuses with corresponding elevated metabolism on FDG PET/CT. Treatment with chemotherapy resulted in complete response on FDG PET/CT and subsequently she underwent autologous stem cell transplantation. NL is a rare manifestation of lymphoma affecting the peripheral nervous system. Nonspecific neuropathic symptoms make clinical diagnosis difficult. Though nerve biopsy is considered the gold standard, MRI and FDG PET/CT are accepted alternatives for making the diagnosis. We review imaging findings in NL, describe the differential diagnosis, and discuss the limitations of the imaging modalities. |
| Databáze: | MEDLINE |
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