Comparative Exposure Assessment Using Silicone Passive Samplers Indicates That Domestic Dogs Are Sentinels To Support Human Health Research.

Autor: Wise CF; Department of Biological Sciences, Environmental and Molecular Toxicology Program, North Carolina State University, 850 Main Campus Drive, Raleigh, North Carolina 27606, United States.; Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, North Carolina 27607, United States., Hammel SC; Nicholas School of the Environment, Duke University, Durham, North Carolina 27708, United States., Herkert N; Nicholas School of the Environment, Duke University, Durham, North Carolina 27708, United States., Ma J; Department of Statistics, North Carolina State University, Raleigh, North Carolina 27607, United States.; Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina 27607, United States., Motsinger-Reif A; Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina 27709, United States., Stapleton HM; Nicholas School of the Environment, Duke University, Durham, North Carolina 27708, United States.; Duke Cancer Institute, Durham, North Carolina 27710, United States., Breen M; Department of Biological Sciences, Environmental and Molecular Toxicology Program, North Carolina State University, 850 Main Campus Drive, Raleigh, North Carolina 27606, United States.; Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, North Carolina 27607, United States.; Duke Cancer Institute, Durham, North Carolina 27710, United States.; Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina 27607, United States.; Center for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina 27607, United States.
Jazyk: angličtina
Zdroj: Environmental science & technology [Environ Sci Technol] 2020 Jun 16; Vol. 54 (12), pp. 7409-7419. Date of Electronic Publication: 2020 May 28.
DOI: 10.1021/acs.est.9b06605
Abstrakt: Silicone wristbands are promising passive samplers to support epidemiological studies in characterizing exposure to organic contaminants; however, investigating associated health risks remains challenging because of the latency period for many chronic diseases that take years to manifest. Dogs provide valuable insights as sentinels for exposure-related human disease because they share similar exposures in the home, have shorter life spans, share many clinical/biological features, and have closely related genomes. Here, we evaluated exposures among pet dogs and their owners using silicone dog tags and wristbands to determine if contaminant levels were correlated with validated exposure biomarkers. Significant correlations between measures on dog tags and wristbands were observed ( r s = 0.38-0.90; p < 0.05). Correlations with their respective urinary biomarkers were stronger in dog tags compared to that in human wristbands ( r s = 0.50-0.71; p < 0.01) for several organophosphate esters. This supports the value of using silicone bands with dogs to investigate health impacts on humans from shared exposures.
Databáze: MEDLINE
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